Description

(Rs)-1-(2-Diphenylphosphino-1-Naphthyl)Isoquinoline is a chiral, atropisomeric phosphine ligand of significant importance in asymmetric catalysis. Its core value lies in its ability to induce high enantioselectivity in transition metal-catalyzed reactions, enabling the production of single-enantiomer compounds. This product is essential for researchers and process chemists in the pharmaceutical, agrochemical, and fine chemical industries who require precise stereochemical control for developing new active ingredients and advanced intermediates.

Application

This specialized ligand is primarily employed in asymmetric synthesis, where it acts as a key component in catalytic systems.

• Asymmetric Hydrogenation: A critical application for the synthesis of chiral amines, amino acids, and other pharmaceutical intermediates with high enantiomeric excess.
• Asymmetric Cross-Coupling Reactions: Used in C-C and C-X bond-forming reactions to create stereogenic centers under mild conditions.
• Pharmaceutical Intermediate Synthesis: For the production of enantiomerically pure active pharmaceutical ingredients (APIs) and key chiral building blocks.
• Agrochemical Synthesis: In the development of chiral herbicides, fungicides, and pesticides where biological activity is often enantiomer-specific.
• Academic and Industrial R&D: Serves as a valuable tool for developing new catalytic methodologies and exploring novel reaction pathways.
• Fine Chemical Manufacturing: For the commercial-scale production of specialty chemicals requiring high optical purity.

Basic Information

Product Name	(Rs)-1-(2-Diphenylphosphino-1-Naphthyl)Isoquinoline
CAS No.	149245-03-4
Molecular Formula	C35H24NP
Molecular Weight	489.55 g/mol
Synonyms	(R)-1-[(S)-2-(Diphenylphosphino)-1-naphthyl]isoquinoline; (R)-1-[(S)-2-(Diphenylphosphino)naphthalen-1-yl]isoquinoline; (R)-1-[(S)-2-(Diphenylphosphanyl)-1-naphthyl]isoquinoline; (R)-1-[(S)-2-(Diphenylphosphanyl)naphthalen-1-yl]isoquinoline; (R)-1-[(S)-2-(Diphenylphosphino)-1-naphthalenyl]isoquinoline; (R)-QUINAP; (R)-Quinap; (R)-Quinaphos; (R)-1-(2-Diphenylphosphino-1-naphthyl)isoquinoline
EINECS	Contact for details

Quality Control

Our (Rs)-1-(2-Diphenylphosphino-1-Naphthyl)Isoquinoline is manufactured under strict quality protocols to ensure batch-to-batch consistency and high purity, which is critical for catalytic performance. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, chiral purity, and impurity profiles. We adhere to rigorous analytical standards to meet the exacting requirements of research and process development.

Storage

Preserve in a tightly closed container, protected from light. Due to its sensitivity to oxidation, long-term storage under an inert atmosphere (argon or nitrogen) is recommended. Store in a cool, dry place at a controlled room temperature (15-25°C). Keep the container tightly sealed to minimize exposure to air and moisture.

Specification

Item	Specification
Appearance	Yellow to orange powder or crystals
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Melting Point	Contact for details
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.