Description

n-Boc-n-Methyl-(R)-3-Cyclohexylalanine is a protected, non-natural amino acid derivative featuring a chiral center and a cyclohexyl side chain. This compound is a critical chiral building block in the synthesis of complex bioactive molecules, particularly in pharmaceutical research and development. It is primarily utilized by medicinal chemists and process development scientists in the pharmaceutical and biotechnology industries for the creation of novel peptide-based therapeutics and other active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of peptide-based drugs and protease inhibitors.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and the development of new chemical entities (NCEs).
• Peptidomimetic Design: Incorporated into peptide backbones to enhance metabolic stability, bioavailability, and receptor selectivity.
• Process Chemistry: Serves as a starting material or intermediate in the scalable, GMP-compliant manufacturing of active pharmaceutical ingredients (APIs).
• Bioconjugation: Can be used to introduce functional handles for linking peptides to other molecules, such as dyes, polymers, or drug delivery systems.
• Academic Research: Employed in organic synthesis and chemical biology studies exploring novel amino acid chemistry.

Basic Information

Product Name	n-Boc-n-Methyl-(R)-3-Cyclohexylalanine
CAS No.	149217-76-5
Molecular Formula	C₁₅H₂₇NO₄
Molecular Weight	285.38 g/mol
Synonyms	(R)-3-(tert-Butoxycarbonyl(methyl)amino)-3-cyclohexylpropanoic acid; (R)-3-((tert-Butoxycarbonyl)(methyl)amino)-3-cyclohexylpropanoic acid; Boc-N-Me-(R)-3-cyclohexyl-Ala-OH; Boc-N-Me-(R)-Cha-OH; N-(tert-Butoxycarbonyl)-N-methyl-(R)-3-cyclohexylalanine; tert-Butyl (R)-(1-carboxy-2-cyclohexylethyl)(methyl)carbamate; (R)-3-Cyclohexyl-3-[(methyl)(tert-butoxycarbonyl)amino]propanoic acid
EINECS	Contact for details

Quality Control

Our n-Boc-n-Methyl-(R)-3-Cyclohexylalanine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high chemical purity, correct stereochemistry, and consistency. Certificates of Analysis (COA) detailing purity (by HPLC), chiral purity, and other critical parameters are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.