Description

(S)-(-)-2,2'-Bis(diphenylphosphino)-1,1'-binaphthyl is a high-value, chiral bidentate phosphine ligand essential for asymmetric catalysis. Its primary value lies in enabling highly enantioselective transformations, which are critical for producing single-isomer pharmaceuticals and fine chemicals. This ligand is particularly needed by R&D chemists and process engineers in the pharmaceutical, agrochemical, and specialty chemical industries for developing and scaling up efficient synthetic routes.

Application

• As a key chiral ligand in asymmetric hydrogenation reactions for the synthesis of enantiomerically pure amino acids and pharmaceutical intermediates.
• As a catalyst component in asymmetric cross-coupling reactions, such as Suzuki-Miyaura and Heck reactions, to form chiral biaryl compounds.
• For enantioselective C-H activation and functionalization processes in modern organic synthesis.
• In the asymmetric isomerization and hydroformylation of olefins to produce chiral aldehydes and alcohols.
• As a critical reagent in academic and industrial research for developing new catalytic methodologies.
• For the production of chiral ligands and catalysts used in the manufacture of active pharmaceutical ingredients (APIs).

Basic Information

Product Name	(S)-(-)-2,2'-Bis(diphenylphosphino)-1,1'-binaphthyl
CAS No.	149022-25-3
Molecular Formula	C44H32P2
Molecular Weight	622.67 g/mol
Synonyms	(S)-BINAP; (S)-(-)-2,2'-Bis(diphenylphosphino)-1,1'-binaphthyl; (S)-2,2'-Bis(diphenylphosphino)-1,1'-binaphthyl; (S)-(-)-BINAP; (S)-1,1'-Binaphthalene-2,2'-diylbis(diphenylphosphine); (S)-2,2'-Bis(diphenylphosphanyl)-1,1'-binaphthyl; (S)-BINAP ligand
EINECS	Contact for details

Quality Control

Our (S)-BINAP is manufactured under strict quality control protocols to ensure high chemical purity and enantiomeric excess, critical for reproducible catalytic performance. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing key parameters such as assay, chiral purity (enantiomeric excess), and impurity profile. We adhere to cGMP principles where applicable to support our customers in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) in a cool, dry place. Due to its sensitivity to oxidation, the container should be flushed with inert gas after each opening to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white powder or crystals
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (HPLC)	≥ 99.0%
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.