Description

27-Carboxy-7-Keto Cholesterol is a key oxidized sterol derivative and an important intermediate in the study of cholesterol metabolism and oxidative stress pathways. This compound is valued for its role as a reference standard and a synthetic precursor in advanced pharmaceutical and biochemical research. It is primarily utilized by research institutions, pharmaceutical R&D departments, and diagnostic manufacturers focused on lipidomics, biomarker discovery, and the development of therapeutic agents targeting metabolic diseases.

Application

• Biochemical Research: Used as a critical reference standard and analytical standard in the study of oxysterols, cholesterol oxidation pathways, and lipid peroxidation.
• Pharmaceutical Development: Serves as a key intermediate in the synthesis of novel drug candidates targeting enzymes involved in cholesterol metabolism and related disorders.
• Diagnostic Reagents: Employed in the development and calibration of diagnostic assays and kits for measuring specific oxysterol biomarkers in clinical samples.
• Metabolic Studies: Applied in cellular and in vitro studies to investigate the biological effects of oxidized cholesterol derivatives on cell signaling and function.
• Academic Research: Utilized in universities and research labs for fundamental studies in biochemistry, cell biology, and the pathophysiology of atherosclerosis.

Basic Information

Product Name	27-Carboxy-7-Keto Cholesterol
CAS No.	148988-30-1
Molecular Formula	C28H44O4
Molecular Weight	444.65 g/mol
Synonyms	7-Ketocholest-5-ene-3β,27-diol-27-oic Acid; 3β-Hydroxy-7-oxocholest-5-en-27-oic Acid; 27-Carboxy-7-oxocholesterol; 7-Keto-27-carboxycholesterol; 27-Nor-5-cholestene-3β,27-diol-7-one-27-oic Acid
EINECS	Contact for details

Quality Control

Our 27-Carboxy-7-Keto Cholesterol is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency suitable for research and development. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards for fine chemicals and can provide material tailored to specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and light-sensitive; appropriate handling procedures should be followed to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.