Description

Ercc6 Protein CAS NO 148972-58-1 is a high-purity, recombinant protein critical for DNA repair and transcription research. This essential biochemical reagent is valued for its role in elucidating the molecular mechanisms of nucleotide excision repair (NER) and its connection to genetic disorders. It is primarily utilized by research institutions, pharmaceutical R&D departments, and diagnostic kit manufacturers engaged in advanced molecular biology, genomics, and targeted therapeutic development.

Application

• Biochemical Research: A key reagent for in vitro studies of nucleotide excision repair (NER) pathways and transcription-coupled repair mechanisms.
• Enzymatic Activity Assays: Used as a standard or active component in assays designed to measure DNA helicase or translocase activity.
• Protein-Protein Interaction Studies: Essential for pull-down assays, co-immunoprecipitation, and mapping interactions within the TFIIH complex.
• Disease Mechanism Investigation: Critical for research into Cockayne syndrome and other xeroderma pigmentosum-related disorders linked to ERCC6 gene mutations.
• Diagnostic Development: Serves as a reference antigen or control protein in the development of ELISA kits and other diagnostic tools for genetic conditions.
• Drug Discovery Screening: Used in high-throughput screening platforms to identify potential therapeutic compounds that modulate NER activity.

Basic Information

Product Name	Ercc6 Protein
CAS No.	148972-58-1
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	CSB Protein; Cockayne Syndrome B Protein; ERCC6; DNA Excision Repair Protein ERCC-6; Transcription Repair Factor; RAD26; TFIIH Basal Transcription Factor Complex Helicase Subunit; ATP-dependent Helicase ERCC6
EINECS	Contact for details

Quality Control

Our Ercc6 Protein is produced under stringent conditions to ensure batch-to-batch consistency and high biological activity. Each lot undergoes rigorous quality testing, including purity analysis by SDS-PAGE and HPLC, functional activity assays, and endotoxin level checks. A comprehensive Certificate of Analysis (COA) detailing identity, purity, concentration, and biological activity is provided with every shipment to support your research and compliance needs.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store frozen at -20°C to -80°C in small aliquots to avoid repeated freeze-thaw cycles. The product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use. Handle under appropriate laboratory conditions.

Specification

Item	Specification
Appearance	White or off-white lyophilized powder or clear solution
Identification (SDS-PAGE)	Single major band at expected molecular weight
Purity (HPLC)	≥ 95%
Protein Concentration	As per COA (typically 0.1 - 1.0 mg/mL)
Biological Activity	Functional in standard DNA binding or ATPase assay
Endotoxin Level	< 1.0 EU/μg
Buffer Composition	Specified on COA

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.