Description

Oncogene Protein Ryk CAS NO 148970-46-1 is a highly purified recombinant protein corresponding to the Receptor-like tyrosine kinase (Ryk), a key signaling molecule involved in critical developmental and cellular processes. This protein is essential for fundamental research into Wnt signaling pathways, stem cell biology, and oncogenesis. It is primarily utilized by academic, pharmaceutical, and biotechnology research institutions focused on cancer biology, neurodevelopment, and regenerative medicine.

Application

• Biochemical Research: Used as a critical reagent for studying non-canonical Wnt signaling pathways and receptor-ligand interactions.
• Cancer Research: Serves as a target protein for investigating its role in tumor progression, metastasis, and as a potential therapeutic target in various cancers.
• Neuroscience Studies: Applied in research on axon guidance, neural development, and synaptic function where Ryk plays a significant role.
• Drug Discovery & Development: Utilized in high-throughput screening (HTS) assays and in vitro studies to identify and validate novel inhibitors or modulators of Ryk activity.
• Antibody Production & Validation: Acts as a pure immunogen for generating and characterizing specific monoclonal or polyclonal antibodies.
• Stem Cell Research: Employed in studies exploring the regulation of stem cell maintenance, differentiation, and tissue regeneration.
• Protein-Protein Interaction Studies: Used in pull-down assays, co-immunoprecipitation (Co-IP), and surface plasmon resonance (SPR) to map interaction networks.
• Diagnostic Development: May serve as a reference standard in the development of diagnostic assays for conditions linked to Ryk dysregulation.

Basic Information

Product Name	Oncogene Protein Ryk
CAS No.	148970-46-1
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Ryk; Receptor-like tyrosine kinase; Nyk; Related to receptor tyrosine kinase; Derailed; DRL; MGC33470; Protein Ryk; Oncogene Ryk; RYK receptor tyrosine kinase; RYK_HUMAN; Tyrosine-protein kinase RYK.
EINECS	Contact for details

Quality Control

Our Oncogene Protein Ryk is produced under stringent conditions to ensure high purity, biological activity, and batch-to-batch consistency. Each lot undergoes comprehensive analytical testing, including SDS-PAGE, Western Blot, and functional activity assays. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting purity, concentration, endotoxin levels, and biological activity. Our quality system is designed to support research requiring reliable and reproducible protein performance.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at ≤ -20°C in small aliquots to avoid repeated freeze-thaw cycles. Avoid exposure to extreme temperatures and humidity. Handle using aseptic techniques in a controlled environment to maintain protein integrity.

Specification

Item	Specification
Appearance	Clear, colorless to slightly opalescent solution
Purity (SDS-PAGE)	≥ 95%
Identification (Western Blot)	Positive
Protein Concentration	As per COA (typically 0.1-1.0 mg/mL)
Formulation Buffer	Specified on COA
Endotoxin Level	< 1.0 EU/μg
Biological Activity	Determined by functional assay (e.g., binding ELISA)
Storage Buffer	PBS or Tris-based buffer, with stabilizer

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.