Description

Amyloid Beta/A4 Protein Precursor770 (403-407) CAS NO 148914-08-3 is a defined synthetic peptide fragment corresponding to a specific sequence of the amyloid precursor protein (APP). This high-purity biochemical is a critical research tool for investigating the molecular mechanisms underlying Alzheimer's disease and related neurodegenerative conditions. It is essential for scientists and pharmaceutical developers in neuroscience research, diagnostic assay development, and therapeutic target validation.

Application

• Biomedical Research: Used as a key antigen for generating and characterizing antibodies specific to the APP/amyloid-beta protein region.
• Assay Development: Serves as a critical standard and control in ELISA, Western blot, and other immunoassays for Alzheimer's disease biomarker detection.
• Mechanistic Studies: Facilitates research into APP processing, amyloid-beta peptide formation, aggregation kinetics, and associated neurotoxicity pathways.
• Drug Discovery Screening: Employed in high-throughput screening (HTS) platforms to identify and evaluate potential therapeutic compounds that modulate APP metabolism or amyloid aggregation.
• Diagnostic Reagent Production: Integrated into the development and calibration of in-vitro diagnostic (IVD) kits for clinical and research use.
• Academic & Institutional Research: Supports fundamental studies in university and government laboratories focused on neurodegeneration and protein biochemistry.

Basic Information

Product Name	Amyloid Beta/A4 Protein Precursor770 (403-407) CAS NO 148914-08-3
CAS No.	148914-08-3
Molecular Formula	C27H44N8O8
Molecular Weight	608.69 g/mol
Synonyms	APP (770) fragment 403-407; Amyloid Beta A4 Protein (770) (403-407); AβPP770 (403-407); Amyloid Precursor Protein 770 fragment; APP770 Peptide (403-407); H-Val-Lys-Met-Asp-Ala-OH; VKMDA peptide; Alzheimer's Disease Associated Peptide Fragment
EINECS	Contact for details

Quality Control

Every batch of our synthetic peptide is manufactured and analyzed under strict cGMP-like guidelines to ensure identity, purity, and consistency. Quality is verified through a comprehensive battery of analytical techniques including HPLC, MS (Mass Spectrometry), and amino acid analysis. A comprehensive Certificate of Analysis (COA) detailing purity, peptide content, and analytical data is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 70% (by weight)
Amino Acid Composition	Within ± 10% of theoretical
Single Impurity (HPLC)	≤ 1.0%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in water or dilute aqueous acetic acid

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.