Description

Ivabradin D6 is a deuterated isotopologue of the selective sinus node inhibitor Ivabradine, specifically designed for use as an internal standard in quantitative analytical methods. This high-purity compound is essential for ensuring the accuracy and reliability of pharmacokinetic and metabolic studies, providing a stable reference point with minimal isotopic interference. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical service providers engaged in the development and quality control of cardiovascular therapeutics.

Application

• Primary use as an internal standard in Liquid Chromatography-Mass Spectrometry (LC-MS) and Gas Chromatography-Mass Spectrometry (GC-MS) for the quantification of Ivabradine.
• Critical component in bioanalytical method development and validation for clinical and preclinical studies.
• Supporting drug metabolism and pharmacokinetics (DMPK) research to study the absorption, distribution, metabolism, and excretion of Ivabradine.
• Used in pharmaceutical quality control laboratories to ensure batch-to-batch consistency and purity of active pharmaceutical ingredients (APIs).
• Facilitates forensic and anti-doping analysis where precise quantification of the parent drug is required.
• Enables stable isotope dilution analysis to achieve superior accuracy in complex biological matrices like plasma, serum, and tissue homogenates.

Basic Information

Product Name	Ivabradin D6
CAS No.	148870-59-1
Molecular Formula	C27H37D6N3O5
Molecular Weight	487.66 g/mol (for D6 isotopologue)
Synonyms	Ivabradine D6; Ivabradine-d6; (3aR,7aS)-1,2,3,7a-Tetrahydro-7-hydroxy-N-[(3S)-1,2,3,4-tetrahydro-6,7-dimethoxy-3-isoquinolinyl]-6,8-dimethyl-7a-(3,4,5-trimethoxyphenyl)-3aH-cyclopenta[b]pyridine-3a-carboxamide-d6; S 16257 D6; Procoralan D6 (deuterated); Corlentor D6 (deuterated); Coraxan D6 (deuterated)
EINECS	Contact for details

Quality Control

Our Ivabradin D6 is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including NMR and Mass Spectrometry for isotopic enrichment confirmation and HPLC for chemical and isotopic purity assessment. We provide comprehensive Certificates of Analysis (COA) detailing batch-specific results for identity, assay, purity, and residual solvents, ensuring compliance with the stringent requirements of analytical reference standard applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to reference spectrum
Identification (MS)	Conforms to structure
Isotopic Purity (Deuterium Enrichment)	≥ 98 atom % D
Chemical Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.