Description

Tecalcet CAS NO 148717-54-8 is a high-purity pharmaceutical intermediate, also known as Cinacalcet Hydrochloride, primarily used in the synthesis of calcimimetic agents. This compound is critical for the production of medications that regulate calcium metabolism, addressing significant needs in endocrinology and nephrology. It is an essential building block for pharmaceutical manufacturers and advanced research institutions developing treatments for hyperparathyroidism and related bone mineral disorders.

Application

• Pharmaceutical Synthesis: Primary use as a key intermediate in the manufacture of Cinacalcet Hydrochloride, the active pharmaceutical ingredient in Sensipar®/Mimpara®.
• Calcimimetic Drug Development: Serves as a crucial precursor in R&D for drugs targeting the calcium-sensing receptor (CaSR).
• Treatment of Secondary Hyperparathyroidism: Used in the production of therapies for patients with chronic kidney disease on dialysis.
• Treatment of Hypercalcemia: Integral to synthesizing medications for hypercalcemia in patients with parathyroid carcinoma.
• Academic & Clinical Research: Employed in biochemical studies of calcium homeostasis and parathyroid hormone (PTH) secretion mechanisms.
• Process Chemistry & Scale-Up: Utilized in optimizing synthetic routes and scaling production for commercial pharmaceutical batches.

Basic Information

Product Name	Tecalcet
CAS No.	148717-54-8
Molecular Formula	C22H22F3N·HCl
Molecular Weight	393.87 g/mol (Free base: 357.42 g/mol)
Synonyms	Cinacalcet Hydrochloride; N-[(1R)-1-(1-Naphthyl)ethyl]-3-[3-(trifluoromethyl)phenyl]propan-1-amine Hydrochloride; AMG 073 Hydrochloride; Sensipar® Intermediate; Mimpara® Intermediate; (R)-N-[1-(1-Naphthyl)ethyl]-3-[3-(trifluoromethyl)phenyl]propylamine Hydrochloride; Tecalcet Hydrochloride
EINECS	Contact for details

Quality Control

Our Tecalcet is manufactured under strict quality management systems. Every batch is subjected to rigorous analytical testing, including chiral purity verification, to ensure compliance with ICH guidelines and customer-specific requirements. A comprehensive Certificate of Analysis (COA) detailing identity, assay, impurity profile, and residual solvents is provided with each shipment to guarantee traceability and consistency for your pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption and degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.5%
Chiral Purity (HPLC)	≥ 99.0% (R-enantiomer)
Related Substances (HPLC)	Total impurities ≤ 1.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.