Description

Bteb Protein CAS NO 148686-29-7 is a specialized biochemical reagent, a brominated triazole derivative, known for its role as a potent and selective inhibitor of the BET family of bromodomains. This compound is critical for advanced research in epigenetics and transcriptional regulation, enabling precise control over gene expression pathways. It is an essential tool for pharmaceutical R&D, academic research in oncology and immunology, and biotechnology companies developing novel targeted therapies.

Application

• Epigenetics Research: Used as a selective chemical probe to inhibit BET bromodomains (BRD2, BRD3, BRD4, BRDT) for studying chromatin biology and gene regulation.
• Oncology Drug Discovery: Serves as a key starting material or reference standard in the development of novel anti-cancer therapeutics targeting transcriptional dependencies.
• Inflammatory Disease Models: Applied in preclinical research to investigate the role of BET proteins in modulating inflammatory and immune responses.
• Biochemical Assay Development: Utilized as a high-purity reference compound in establishing screening assays for bromodomain activity and inhibitor potency.
• Chemical Biology Studies: Employed to elucidate specific protein-protein interactions and downstream signaling cascades controlled by BET proteins.
• Academic & Institutional Research: A fundamental reagent for universities and research institutes exploring novel mechanisms in cell differentiation, proliferation, and disease progression.

Basic Information

Product Name	Bteb Protein
CAS No.	148686-29-7
Molecular Formula	C19H21BrN6O2
Molecular Weight	445.32 g/mol
Synonyms	BET Bromodomain Inhibitor; (+)-JQ1; (S)-JQ1; (S)-tert-Butyl 2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate; JQ-1; GSK525762A analog; BRD4 Inhibitor; Thienotriazolodiazepine inhibitor
EINECS	Contact for details

Quality Control

Our Bteb Protein is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for sensitive research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant standards for research-grade biochemicals, and custom synthesis to meet specific purity requirements (e.g., >98% or >99% by HPLC) is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, consider under an inert atmosphere. Allow the vial to warm to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Solubility	Soluble in DMSO, DMF; sparingly soluble in ethanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.