Description

Hydroxyitraconazole CAS NO 148626-66-8 is a key pharmaceutical intermediate and metabolite of the broad-spectrum antifungal agent itraconazole. This compound is critical for research and development in antifungal therapies, serving as a vital reference standard and a building block for novel drug formulations. It is essential for pharmaceutical manufacturers, analytical laboratories, and research institutions focused on developing and quality-controlling advanced antifungal medications.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of itraconazole and related triazole antifungal agents.
• Reference Standard: Used as a certified reference material (CRM) for analytical method development, validation, and quality control in pharmaceutical testing.
• Metabolite Studies: Employed in pharmacokinetic and pharmacodynamic research to study the metabolism, distribution, and efficacy of itraconazole.
• Active Pharmaceutical Ingredient (API) Development: Serves as a key starting material (KSM) in the R&D of new antifungal drug candidates and generic formulations.
• Biochemical Research: Utilized in in-vitro studies to investigate the mechanism of action of azole antifungals against various fungal strains.

Basic Information

Product Name	Hydroxyitraconazole
CAS No.	148626-66-8
Molecular Formula	C35H38Cl2N8O4
Molecular Weight	705.63 g/mol
Synonyms	2-Butanol, 1-[(4R,5S)-5-[[(2R,4S)-2-(2,4-Dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]-4-phenyl-4-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-2-yl]-2-methyl-, (2R,4S)-rel-; Hydroxy Itraconazole; Itraconazole Hydroxy Metabolite; Itraconazole Impurity; Itraconazole Related Compound; OH-Itraconazole
EINECS	Contact for details

Quality Control

Our Hydroxyitraconazole is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets high-purity standards suitable for pharmaceutical research and development. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.