Description

Fmoc-Pro-Ol CAS NO 148625-77-8 is a high-purity, protected amino acid derivative specifically designed for solid-phase peptide synthesis (SPPS). This compound is a critical building block for the controlled assembly of complex peptides and peptidomimetics, offering excellent coupling efficiency and minimal racemization. It is an essential raw material for pharmaceutical R&D, biotechnology, and academic research focused on developing novel therapeutic peptides, diagnostic agents, and biochemical probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): A fundamental Fmoc-protected proline derivative used as a key monomer for the automated or manual synthesis of custom peptides.
• Pharmaceutical Research & Development: Serves as a crucial intermediate in the discovery and production of peptide-based drugs, including hormones, enzyme inhibitors, and antimicrobial agents.
• Bioconjugation & Probe Development: Used to introduce proline residues into labeled peptides for biochemical assays, imaging studies, and targeted drug delivery systems.
• Combinatorial Chemistry Libraries: Employed in the generation of diverse peptide libraries for high-throughput screening against biological targets.
• Academic & Contract Research: Essential for universities and CROs conducting fundamental research in peptide chemistry, protein engineering, and medicinal chemistry.
• Production of Peptide Fragments: Used in the synthesis of specific peptide sequences required for antibody production, epitope mapping, and structural studies.

Basic Information

Product Name	Fmoc-Pro-Ol
CAS No.	148625-77-8
Molecular Formula	C₂₁H₂₁NO₄
Molecular Weight	351.40 g/mol
Synonyms	Fmoc-L-Proline-ol; Fmoc-Pro-ol; 9-Fluorenylmethyloxycarbonyl-prolinol; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-prolinol; (S)-1-(((9H-Fluoren-9-yl)methoxy)carbonyl)pyrrolidine-2-methanol; Fmoc-Proline-ol; N-Fmoc-L-prolinol; Prolinol, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-
EINECS	Contact for details

Quality Control

Our Fmoc-Pro-Ol is manufactured under strict quality management systems to ensure batch-to-batch consistency and high chemical purity suitable for sensitive synthetic applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and chiral integrity assessment. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Optical Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.