Description

tert-Butyl 4-(5-Amino-2-Methoxyphenyl)Piperazine-1-Carboxylate is a high-purity, protected piperazine derivative serving as a critical building block in advanced organic synthesis. Its primary value lies in providing a versatile and reactive amine handle for constructing complex pharmaceutical intermediates and active pharmaceutical ingredients (APIs). This compound is essential for research and development chemists and process scale-up teams in the pharmaceutical, agrochemical, and fine chemical industries who require reliable, high-quality synthetic precursors.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders and other therapeutic areas.
• API Synthesis: Used in constructing the core scaffold or side chains of complex Active Pharmaceutical Ingredients (APIs).
• Chemical Research & Development: Serves as a versatile building block for medicinal chemistry, enabling structure-activity relationship (SAR) studies and lead optimization.
• Agrochemical Intermediates: Employed in the development of advanced crop protection agents and herbicides.
• Custom Synthesis & Contract Manufacturing: A valuable starting material for custom synthesis projects and contract research organizations (CROs/CMOs).
• Ligand & Catalyst Development: Potential use in creating novel ligands for catalysis or metal-organic frameworks (MOFs).

Basic Information

Product Name	tert-Butyl 4-(5-Amino-2-Methoxyphenyl)Piperazine-1-Carboxylate
CAS No.	148546-91-2
Molecular Formula	C16H25N3O3
Molecular Weight	307.39 g/mol
Synonyms	1-Boc-4-(5-Amino-2-methoxyphenyl)piperazine; tert-Butyl 4-(5-amino-2-methoxyphenyl)-1-piperazinecarboxylate; 4-(5-Amino-2-methoxyphenyl)piperazine-1-carboxylic acid tert-butyl ester; 1-Piperazinecarboxylic acid, 4-(5-amino-2-methoxyphenyl)-, 1,1-dimethylethyl ester; Boc-4-(5-Amino-2-methoxyphenyl)piperazine; 148546-91-2; 5-Amino-2-methoxy-N-Boc-phenylpiperazine
EINECS	Contact for details

Quality Control

Our tert-Butyl 4-(5-Amino-2-Methoxyphenyl)Piperazine-1-Carboxylate is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to confirm identity, purity, and the absence of critical impurities. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting compliance with agreed specifications. We support cGMP standards for pharmaceutical applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%, Total impurities ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.