Description

Fmoc-(Fmochmb)Phe-Oh is a specialized, orthogonally protected amino acid derivative designed for advanced peptide synthesis. This compound matters for its critical role in solid-phase peptide synthesis (SPPS), where it provides enhanced protection strategies to prevent side reactions and enable the construction of complex peptide sequences. It is primarily needed by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers focused on developing peptide-based therapeutics, diagnostic tools, and biochemical probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key building block for the controlled incorporation of phenylalanine with orthogonal protecting groups.
• Pharmaceutical Research: For the development and scale-up of novel peptide drugs and active pharmaceutical ingredients (APIs).
• Combinatorial Chemistry: Used in libraries for high-throughput screening to discover new bioactive compounds.
• Bioconjugation: Serves as a precursor for creating peptide-protein or peptide-small molecule conjugates.
• Academic Research: A valuable reagent in university and institutional labs studying peptide structure, function, and synthesis methodologies.
• Production of Difficult Sequences: Facilitates the synthesis of peptides containing aggregation-prone or sterically hindered sequences.

Basic Information

Product Name	Fmoc-(Fmochmb)Phe-Oh
CAS No.	148515-88-2
Molecular Formula	C₃₆H₃₅NO₆
Molecular Weight	577.67 g/mol
Synonyms	Fmoc-Phe(Fmochmb)-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-O-[(9H-fluoren-9-ylmethoxy)carbonyl]-N-(2-methyl-2-propanyl)-L-tyrosine; Fmoc-L-Phe(Fmochmb)-OH; Fmoc-O-(Fmochmb)-L-tyrosine; Nα-Fmoc-Nε-Fmochmb-L-phenylalanine; (2S)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-3-[4-[(2-methylpropan-2-yloxycarbonyl-(9H-fluoren-9-ylmethoxy))amino]phenyl]propanoic acid; Fmoc-Tyr(Fmochmb)-OH analog
EINECS	Contact for details

Quality Control

Our Fmoc-(Fmochmb)Phe-Oh is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for peptide synthesis. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and batch-to-batch consistency for your critical research and production needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment. For long-term storage, consider desiccant and under an inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.