Description

Adrenomedullin (Human) CAS NO 148498-78-6 is a potent, multifunctional regulatory peptide hormone, originally isolated from human pheochromocytoma tissue. This bioactive peptide plays a critical role in cardiovascular homeostasis, vasodilation, and cellular growth regulation, making it a valuable research tool and a promising candidate for therapeutic development. It is essential for researchers and developers in the fields of cardiovascular disease research, oncology, and endocrinology, as well as for pharmaceutical companies investigating novel peptide-based therapeutics.

Application

• Biomedical Research: Fundamental studies on cardiovascular physiology, blood pressure regulation, and endothelial function.
• Drug Discovery & Development: Target validation and screening for novel therapeutics targeting heart failure, hypertension, and sepsis.
• Clinical Diagnostics: Potential use as a biomarker in assay development for conditions like heart failure, pulmonary hypertension, and renal disease.
• Cell Culture & In Vitro Studies: Investigation of its effects on cell proliferation, apoptosis, and angiogenesis in various cell lines.
• Endocrinology Research: Exploration of its role in hormone regulation and metabolic processes.
• Academic & Institutional Research: A key reagent for universities and research institutes studying peptide biology and signal transduction pathways.

Basic Information

Product Name	Adrenomedullin (Human)
CAS No.	148498-78-6
Molecular Formula	C164H256N50O48S2
Molecular Weight	~ 6029.8 g/mol
Synonyms	Human Adrenomedullin; ADM; AM; hADM; Preproadrenomedullin (153-185), human; Adrenomedullin-52; AM 1-52; Adrenomedullin (1-52), human; ADM (1-52); Adrenomedullin-1; P30952
EINECS	Contact for details

Quality Control

Our Adrenomedullin (Human) is produced under stringent quality management systems to ensure the highest standards of purity and biological activity. Each batch is subjected to comprehensive analytical testing, including HPLC for purity verification, mass spectrometry for identity confirmation, and endotoxin testing. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all relevant specifications and test results to support your research and development needs.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store lyophilized powder at -20°C or below. Once reconstituted, aliquot and store at -80°C to minimize freeze-thaw cycles. The product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use in a low-humidity environment.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Molecular Weight	6029.8 ± 2.0 Da (by MS)
Water Content (KF)	≤ 5.0%
Acetate Content (HPIC)	≤ 10.0%
Endotoxin	< 1.0 EU/mg

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.