Description

Pyr3 Protein CAS NO 148412-40-2 is a specialized chemical compound widely recognized for its role as a selective inhibitor of TRPC3 calcium channels. This high-purity biochemical is essential for advanced life science research and pharmaceutical development, enabling precise modulation of calcium signaling pathways. It is a critical reagent for researchers and manufacturers in the fields of neurobiology, cardiovascular disease research, and the development of targeted therapeutic agents.

Application

• Neuroscience Research: Used as a selective pharmacological tool to study the function of TRPC3 channels in neuronal signaling, synaptic plasticity, and related neurological disorders.
• Cardiovascular Research: Applied in investigations of cardiac hypertrophy, vascular smooth muscle contraction, and endothelial function where TRPC3 channels play a key regulatory role.
• Drug Discovery & Development: Serves as a reference standard and lead compound in screening assays and preclinical studies for novel therapeutics targeting calcium dysregulation.
• Cellular Signaling Studies: Employed to dissect calcium-dependent signaling cascades in various cell types, helping to elucidate mechanisms of cell proliferation, differentiation, and apoptosis.
• Biochemical Assay Development: Utilized in the development and validation of high-throughput screening (HTS) platforms and in vitro diagnostic methods.
• Academic & Institutional Research: A key reagent for universities and research institutes conducting fundamental studies in cell biology and physiology.

Basic Information

Product Name	Pyr3 Protein CAS NO 148412-40-2
CAS No.	148412-40-2
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Pyr3; TRPC3 Channel Inhibitor Pyr3; 1-[4-(2,3,3-Trichloroacrylamido)phenyl]-5-pyrazolone; Ethyl 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate (common misassignment, verify); 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, diethyl ester; BTP2 analog; Calcium channel inhibitor; Protein kinase research chemical
EINECS	Contact for details

Quality Control

Every batch of Pyr3 Protein is manufactured and analyzed under strict quality management protocols to ensure identity, purity, and consistency suitable for research applications. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) detailing batch-specific results for purity, identity, and impurities are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Related Substances (HPLC)	Total impurities ≤ 3.0% Any single unknown impurity ≤ 1.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.