Description

Haloperidol n-Oxide is a key pharmaceutical intermediate and metabolite of the antipsychotic drug Haloperidol. This compound is of significant importance for research and development in neuropharmacology and analytical chemistry. It is primarily utilized by pharmaceutical manufacturers and research institutions for the synthesis of novel derivatives, metabolic pathway studies, and as a certified reference standard for quality control and bioanalytical testing.

Application

• Pharmaceutical Intermediate: Used in the research and synthesis of novel antipsychotic drug candidates and related compounds.
• Metabolite Standard: Serves as a certified reference material (CRM) for the identification and quantification of Haloperidol metabolites in pharmacokinetic and bioequivalence studies.
• Analytical Chemistry: Employed as a high-purity standard for method development and validation in HPLC, LC-MS, and other chromatographic techniques.
• Biochemical Research: Used in in-vitro studies to investigate the metabolic pathways, mechanisms of action, and oxidative transformation of Haloperidol.
• Quality Control: Essential for pharmaceutical quality assurance laboratories to verify the purity of active pharmaceutical ingredients (APIs) and detect related substances.

Basic Information

Product Name	Haloperidol n-Oxide
CAS No.	148406-51-3
Molecular Formula	C₂₁H₂₄ClFNO₂
Molecular Weight	375.87 g/mol
Synonyms	4-(4-Chlorophenyl)-1-[4-(4-fluorophenyl)-4-oxobutyl]-4-piperidinol 1-oxide; Haloperidol N-Oxide; Haloperidol 1-Oxide; 1-[4-(4-Fluorophenyl)-4-oxobutyl]-4-(4-chlorophenyl)-4-hydroxypiperidine 1-oxide; HP N-Oxide; Haloperidol Metabolite II
EINECS	Contact for details

Quality Control

Our Haloperidol n-Oxide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identification by IR and NMR, purity assay by HPLC, and control of specified impurities. A detailed Certificate of Analysis (COA) is provided with every shipment, ensuring traceability and compliance with your research or manufacturing standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.