Description

Spi-B Protein CAS NO 148350-00-9 is a transcription factor belonging to the ETS family, playing a critical role in the regulation of gene expression within the immune system. Its primary commercial and research value lies in its function in B-cell and dendritic cell development, making it a vital reagent for immunological studies and biopharmaceutical development. This high-purity protein is essential for researchers and developers in academic research, immunology, and drug discovery sectors, particularly those investigating hematopoiesis, lymphoma, and autoimmune diseases.

Application

• Biochemical Research: Used as a key reagent in studies of transcriptional regulation, signal transduction pathways, and immune cell differentiation.
• Drug Discovery & Target Validation: Serves as a target protein for screening potential therapeutic compounds aimed at modulating immune responses in autoimmune disorders or cancers.
• Diagnostic Development: Employed in the development of assays and kits for detecting specific immune cell functions or related biomarkers.
• Cell Culture & Differentiation Studies: Applied in *in vitro* systems to study and direct the development of B-lymphocytes and dendritic cells from progenitor cells.
• Protein-Protein Interaction Studies: Utilized to investigate interactions with other transcription factors, co-activators, or repressors within the nucleus.
• Antibody Production & Specificity Testing: Acts as a pure antigen for generating and validating specific antibodies used in research and diagnostics.

Basic Information

Product Name	Spi-B Protein
CAS No.	148350-00-9
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Spi-B transcription factor; SPI-B; ETS transcription factor Spi-B; Transcription factor Spi-B; SPI-B_HUMAN; Spi-1/PU.1 related oncogene; PRB; PRB1; Spi-B PRB
EINECS	Contact for details

Quality Control

Our Spi-B Protein is produced and tested under stringent conditions to ensure high purity, biological activity, and batch-to-batch consistency. Each lot undergoes comprehensive analytical characterization, including assessment of purity, identity, and functional activity. A detailed Certificate of Analysis (COA) documenting all test results is provided with every shipment to guarantee compliance with your research specifications.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below in a non-frost-free freezer. Avoid repeated freeze-thaw cycles. The product is hygroscopic (moisture-sensitive); allow the vial to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White or off-white lyophilized powder
Identification (SDS-PAGE)	Single major band at expected molecular weight
Purity (HPLC)	≥ 95%
Protein Content (UV Spectroscopy)	≥ 80%
Endotoxin (LAL Test)	< 1.0 EU/µg
Biological Activity (Functional Assay)	Contact for details
Solubility	Soluble in appropriate aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.