Description

P40 Protein, Human is a recombinant human cytokine belonging to the interleukin-12 (IL-12) family, specifically functioning as a subunit. This protein plays a crucial role in immunoregulation, particularly in the differentiation of T helper cells and the modulation of inflammatory responses. It is an essential research reagent for scientists in immunology, oncology, and biopharmaceutical development, serving as a key component in cell culture, assay development, and therapeutic research. The product is supplied as a high-purity, lyophilized powder to ensure consistent biological activity and stability.

Application

• Immunological Research: Used to study T cell differentiation, NK cell activation, and the regulation of Th1/Th2 immune responses.
• Cell Culture & Differentiation: A critical additive in media for the in vitro expansion and differentiation of specific immune cell populations.
• Assay Development: Serves as a standard or critical reagent in ELISA, cell-based bioassays, and other diagnostic test systems.
• Drug Discovery & Development: Used in high-throughput screening (HTS) and functional studies for novel immunotherapies and anti-inflammatory drugs.
• Biopharmaceutical Production: Employed in process development and quality control for biologic drugs targeting immune pathways.
• Academic & Preclinical Studies: Facilitates research into autoimmune diseases, cancer immunotherapy, and infectious disease mechanisms.

Basic Information

Product Name	P40 Protein, Human
CAS No.	148349-28-4
Molecular Formula	C~800H~1300N~220O~240S~10 (Approximate for glycosylated protein)
Molecular Weight	~40 kDa (Glycosylated)
Synonyms	Interleukin 12 Subunit Beta; IL-12B; IL12B; Cytotoxic Lymphocyte Maturation Factor 40 kDa subunit; CLMF p40; NKSF2; NK Cell Stimulatory Factor Chain 2; Natural Killer Cell Stimulatory Factor 2; p40 subunit of IL-12; Recombinant Human IL-12 p40
EINECS	Contact for details

Quality Control

Our P40 Protein, Human is manufactured under stringent conditions to ensure the highest standards of purity and biological activity. Each batch undergoes rigorous analytical testing, including SDS-PAGE, HPLC, and endotoxin level analysis. A comprehensive Certificate of Analysis (COA) detailing purity, potency (specific activity), endotoxin levels, and sterility (where applicable) is provided. Our quality system is designed to support research and development requiring consistent, reliable, and well-characterized biological reagents.

Storage

Preserve in a tightly closed container, protected from light. For long-term storage, keep the lyophilized powder at -20°C or below. Upon reconstitution, aliquot and store at -80°C to avoid repeated freeze-thaw cycles. The product is hygroscopic (moisture-sensitive); ensure the vial is at room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White or off-white lyophilized powder
Identification (SDS-PAGE)	Single band at ~40 kDa under reducing conditions
Purity (HPLC)	≥ 95%
Endotoxin Level (LAL)	< 1.0 EU/µg
Biological Activity (Cell-based assay)	Contact for details
Reconstitution	Sterile PBS, pH 7.4

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.