Description

Polymyositis-Scleroderma Overlap Syndrome-Related Nucleolar Protein CAS NO 148349-10-4 is a high-purity biochemical reference standard and research reagent. This compound is critical for advancing scientific understanding of autoimmune connective tissue diseases, particularly in the study of autoantibody specificity and disease pathogenesis. It is primarily utilized by research institutions, diagnostic laboratories, and pharmaceutical R&D departments focused on immunology and rheumatology.

Application

• Autoimmune Disease Research: Key antigen for investigating the immunopathology of Polymyositis-Scleroderma Overlap Syndrome and related conditions.
• Diagnostic Assay Development: Used as a critical reference standard in the development and calibration of ELISA, immunoblot, and line immunoassay (LIA) kits for autoantibody detection.
• Biomarker Validation: Serves as a purified target antigen for validating novel biomarkers in patient serum samples.
• Pharmaceutical Screening: Employed in high-throughput screening (HTS) platforms to identify potential therapeutic compounds that modulate autoantibody interactions.
• Clinical Study Standards: Provides a consistent, well-characterized antigen for use in longitudinal clinical studies and trial endpoint analysis.
• Academic & Institutional Research: Essential reagent for basic science research into nucleolar protein function and autoimmunity triggers.

Basic Information

Product Name	Polymyositis-Scleroderma Overlap Syndrome-Related Nucleolar Protein
CAS No.	148349-10-4
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	PM-Scl Autoantigen; PM/Scl-100 Nucleolar Protein; Polymyositis-Scleroderma Overlap Syndrome Autoantigen; PM-Scl Complex 100 kDa Subunit; Anti-PM/Scl Antibody Target Protein; Nucleolar Autoantigen PM-Scl 100; 100 kDa Nucleolar Protein PM-Scl
EINECS	Contact for details

Quality Control

Our Polymyositis-Scleroderma Overlap Syndrome-Related Nucleolar Protein is produced under stringent conditions to ensure batch-to-batch consistency and high biological activity. Each lot undergoes comprehensive analytical characterization, including purity assessment and identity confirmation. Certificates of Analysis (COA) detailing purity, identity, and stability are provided with every shipment to support your research and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to reach room temperature in a dry environment before opening to minimize moisture uptake. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (IR / MS)	Conforms to reference standard
Purity (SDS-PAGE / HPLC)	≥ 95%
Protein Content (BCA)	≥ 90%
Biological Activity (ELISA)	Reactive with confirmed anti-PM/Scl positive sera
Endotoxin Level (LAL)	< 1.0 EU/mg
Solubility	Soluble in appropriate aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.