Description

Noggin Protein CAS NO 148294-77-3 is a recombinant protein belonging to the bone morphogenetic protein (BMP) antagonist family, playing a crucial role in developmental signaling pathways. This high-purity protein is essential for researchers and developers in life sciences, enabling precise control over cell differentiation and tissue formation processes. It serves as a critical reagent for advanced applications in stem cell research, regenerative medicine, and developmental biology studies.

Application

• Stem Cell Research & Differentiation: Used to inhibit BMP signaling, promoting the maintenance of pluripotency or directing differentiation into specific neural and other cell lineages.
• Developmental Biology Studies: A key tool for investigating embryonic patterning, neural tube development, and organogenesis in model systems.
• Regenerative Medicine & Tissue Engineering: Employed in protocols to generate specific cell types for potential therapeutic applications and in vitro tissue modeling.
• Biochemical & Cell-Based Assays: Serves as a critical component in assays screening for modulators of the BMP/TGF-β signaling pathway.
• Neuroscience Research: Applied in studies focusing on neurogenesis, neural crest cell development, and central nervous system formation.
• Production of Specialty Cell Culture Media: Incorporated into defined media formulations for the expansion and differentiation of sensitive primary cells and stem cells.

Basic Information

Product Name	Noggin Protein
CAS No.	148294-77-3
Molecular Formula	Information available upon request.
Molecular Weight	Information available upon request.
Synonyms	Noggin; Recombinant Noggin; Noggin Protein, Human; NOG Protein; NOG_HUMAN; SYM1; SYNS1; Bone Morphogenetic Protein Antagonist Noggin; Synovial Sarcoma, X Breakpoint 1
EINECS	Contact for details.

Quality Control

Our Noggin Protein is produced under stringent quality systems. Each batch undergoes comprehensive analytical testing, including identity confirmation, purity assessment, and biological activity determination to ensure consistency and performance. Certificates of Analysis (COA) detailing purity, endotoxin levels, sterility (where applicable), and specific activity are provided. We adhere to ISO 9001 quality management principles, and our processes are designed to support research and pre-clinical development needs.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below. Avoid repeated freeze-thaw cycles. This product is hygroscopic (moisture-sensitive); allow the vial to reach room temperature before opening to minimize condensation and moisture uptake.

Specification

Item	Specification
Appearance	White or off-white lyophilized powder or clear solution
Identification (SDS-PAGE/Western Blot)	Consistent with recombinant Noggin protein
Purity (SDS-PAGE)	> 95%
Endotoxin Level (LAL)	< 1.0 EU/µg
Biological Activity (Cell-based assay)	ED50 within defined range
Sterility (for aseptic fills)	Sterile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.