Description

Prp38 Protein CAS NO 148294-68-2 is a highly purified recombinant protein derived from the PRP38 gene, a critical component of the pre-mRNA splicing machinery. This protein is essential for researchers and developers in the life sciences sector, offering a reliable tool for studying spliceosome assembly, function, and the molecular basis of genetic disorders. It is primarily utilized by biotechnology firms, academic research institutions, and pharmaceutical companies engaged in molecular biology, proteomics, and drug discovery programs targeting RNA processing pathways.

Application

• Biochemical Research: Used as a key reagent for in vitro studies of spliceosome dynamics, assembly, and catalytic activity.
• Enzymology Studies: Serves as a substrate or co-factor in enzymatic assays to investigate the mechanisms of pre-mRNA splicing.
• Protein-Protein Interaction Analysis: Employed in pull-down assays, co-immunoprecipitation (Co-IP), and yeast two-hybrid screens to map the spliceosome interactome.
• Antigen Production: Acts as an immunogen for generating specific antibodies used in Western blotting, immunohistochemistry, and ELISA.
• Drug Discovery Screening: Integrated into high-throughput screening (HTS) platforms to identify novel compounds that modulate splicing activity for therapeutic development.
• Diagnostic Development: Potential use in developing assays for detecting abnormalities in splicing factors associated with specific diseases.

Basic Information

Product Name	Prp38 Protein
CAS No.	148294-68-2
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	PRP38 Protein; Pre-mRNA-processing-splicing factor 38; PRPF38A; PRP38 pre-mRNA processing factor 38 homolog A; Splicing factor PRP38; PRP38 splicing factor; Recombinant Human PRP38 Protein; hPRP38
EINECS	Contact for details

Quality Control

Our Prp38 Protein is produced under stringent conditions to ensure high purity and batch-to-batch consistency. Each lot undergoes comprehensive analytical testing, including SDS-PAGE, Western blot analysis, and functional activity assays. A comprehensive Certificate of Analysis (COA) detailing purity, concentration, biological activity, and endotoxin levels is provided with every shipment to support your research and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store frozen at -20°C to -80°C. Avoid repeated freeze-thaw cycles. The product is hygroscopic (moisture-sensitive); ensure the vial is equilibrated to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White or off-white lyophilized powder or clear solution
Purity (SDS-PAGE)	≥ 95%
Identification (Western Blot)	Positive
Biological Activity	Confirmed by functional assay
Endotoxin Level	< 1.0 EU/µg (LAL test)
Protein Concentration	As per COA
Buffer Composition	Specified on COA

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.