Description

7-(2-Amino-2-Phenylacetamido)-3-(1H-1,2,3-Triazol-4-Yl)Methylthiomethyl-3-Cephem-4-Carboxylic Acid is a key advanced pharmaceutical intermediate in the synthesis of modern cephalosporin antibiotics. Its complex molecular structure, featuring a triazole side chain, is engineered to enhance antibacterial potency and spectrum against resistant pathogens. This high-purity intermediate is essential for research institutions and pharmaceutical manufacturers developing next-generation β-lactam antibiotics to address critical healthcare challenges.

Application

• Pharmaceutical Intermediate: Primary building block for the synthesis of novel third and fourth-generation cephalosporin antibiotics.
• Antibacterial Drug Development: Critical for R&D programs focused on creating new agents to combat multi-drug resistant (MDR) Gram-positive and Gram-negative bacteria.
• Chemical Synthesis Research: Used in academic and industrial laboratories to study structure-activity relationships (SAR) within the cephem class.
• Active Pharmaceutical Ingredient (API) Manufacturing: Serves as a precursor in the controlled, multi-step synthesis of finished antibiotic APIs under GMP conditions.
• Process Chemistry & Scale-Up: Employed in optimizing synthetic routes and scaling production from laboratory to pilot plant and commercial manufacturing.

Basic Information

Product Name	7-(2-Amino-2-Phenylacetamido)-3-(1H-1,2,3-Triazol-4-Yl)Methylthiomethyl-3-Cephem-4-Carboxylic Acid
CAS No.	148234-35-9
Molecular Formula	C21H21N7O4S2
Molecular Weight	499.57 g/mol
Synonyms	(6R,7R)-7-[(2R)-2-Amino-2-phenylacetamido]-3-[(1H-1,2,3-triazol-4-ylsulfanyl)methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid; Cefcapene Pivoxil Intermediate; Cefcapene Acid; 7-[(Amino-phenyl-acetyl)amino]-3-(1H-1,2,3-triazol-4-ylsulfanylmethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid; Cefcapene Precursor; 148234-35-9; Cephalosporin Triazole Intermediate
EINECS	Contact for details

Quality Control

Our 7-(2-Amino-2-Phenylacetamido)-3-(1H-1,2,3-Triazol-4-Yl)Methylthiomethyl-3-Cephem-4-Carboxylic Acid is manufactured under strict quality management systems. Each batch is subjected to rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the stringent specifications required for pharmaceutical synthesis. Certificates of Analysis (COA) detailing all test results are provided and can be tailored to meet specific customer or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.