Description

(-)-o-Desmethyltramadol, Hydrochloride is a high-purity, enantiomerically pure pharmaceutical intermediate and reference standard. This compound is a key metabolite and synthetic precursor of the analgesic tramadol, offering significant value for research and development in neuropharmacology. It is essential for pharmaceutical manufacturers, analytical laboratories, and research institutions focused on pain management, drug metabolism studies, and the synthesis of novel active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: Critical for the synthesis and process development of tramadol and its related analogs.
• Analytical Reference Standard: Used in HPLC, LC-MS, and GC-MS methods for the quantification and identification of tramadol metabolites in pharmacokinetic and bioequivalence studies.
• Metabolite Research: Serves as a pure standard for investigating the pharmacological activity, toxicity, and metabolic pathways of tramadol.
• Medicinal Chemistry: A valuable building block for designing and synthesizing new chemical entities with potential analgesic properties.
• Quality Control: Employed in pharmaceutical quality assurance laboratories to validate analytical methods and ensure batch-to-batch consistency of API production.
• Forensic Analysis: Used as a certified reference material in forensic toxicology for the accurate detection of tramadol and its metabolites.

Basic Information

Product Name	(-)-o-Desmethyltramadol, Hydrochloride
CAS No.	148218-19-3
Molecular Formula	C15H23NO2•HCl
Molecular Weight	285.81 g/mol
Synonyms	(-)-O-Desmethyltramadol HCl; (1R,2R)-2-[(Dimethylamino)methyl]-1-(3-methoxyphenyl)cyclohexanol Hydrochloride; O-Desmethyltramadol (-)-isomer Hydrochloride; M1 Metabolite of Tramadol Hydrochloride; (1R,2R)-Tramadol Metabolite M1 HCl; TRM-M1 HCl; UNII-8P1Q15M152 (component); (-)-O-DSMT HCl
EINECS	Contact for details

Quality Control

Our (-)-o-Desmethyltramadol, Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Individual impurity ≤0.5%; Total impurities ≤1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.