Description

trans-3-Methoxy-4-Hydroxy-1-Boc-Pyrrolidine CAS NO 148214-86-2 is a high-purity, advanced pharmaceutical intermediate featuring a protected pyrrolidine scaffold. This compound is critical for the synthesis of complex molecules, particularly in medicinal chemistry, where it serves as a key chiral building block. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs) and fine chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel drug candidates, particularly for central nervous system (CNS) and other therapeutic areas.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization to introduce specific stereochemistry and functional groups.
• Peptidomimetic Synthesis: Serves as a constrained proline analog for constructing peptidomimetics and macrocyclic compounds with enhanced metabolic stability.
• Asymmetric Synthesis: Employed as a chiral auxiliary or building block in asymmetric synthesis to control stereochemistry in complex molecular architectures.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations providing custom synthesis and process development services for the pharmaceutical industry.
• Academic Research: Used in university and institutional labs for methodological development in organic synthesis and chemical biology.

Basic Information

Item	Details
Product Name	trans-3-Methoxy-4-Hydroxy-1-Boc-Pyrrolidine
CAS No.	148214-86-2
Molecular Formula	C11H21NO5
Molecular Weight	247.29 g/mol
Synonyms	(3R,4S)-1-(tert-Butoxycarbonyl)-4-hydroxy-3-methoxypyrrolidine; (3R,4S)-1-Boc-4-hydroxy-3-methoxypyrrolidine; trans-1-Boc-3-methoxy-4-hydroxypyrrolidine; 1-Boc-3-methoxy-4-hydroxy-pyrrolidine; tert-Butyl (3R,4S)-4-hydroxy-3-methoxypyrrolidine-1-carboxylate; 1-N-Boc-3-methoxy-4-hydroxypyrrolidine; (3R,4S)-1-Boc-3-methoxy-4-hydroxypyrrolidine
EINECS	Contact for details

Quality Control

Our trans-3-Methoxy-4-Hydroxy-1-Boc-Pyrrolidine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure it meets the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing identity, purity (by HPLC), chiral purity, and residual solvent levels is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C for long-term stability. This product is hygroscopic (moisture-sensitive) and should be handled under a dry inert atmosphere (e.g., nitrogen or argon) when opening the container to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.