Description

Pyrrolidine, 1-Acetyl-2-(2,2,2-Trifluoro-1-Hydroxyethylidene)-, (E)- (9Ci) is a high-purity, specialized fluorinated pyrrolidine derivative designed for advanced synthetic chemistry. This compound serves as a critical building block and intermediate in the development of novel active pharmaceutical ingredients (APIs) and agrochemicals. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries seeking to incorporate unique trifluoromethyl and hydroxyl functionalities into complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders and metabolic diseases.
• Agrochemical Research: Used in the development of advanced herbicides, fungicides, and insecticides where the trifluoromethyl group enhances biological activity and environmental stability.
• Fluorine Chemistry: An essential reagent for introducing fluorinated motifs into complex organic molecules, leveraging the unique properties of fluorine to modulate lipophilicity, metabolic stability, and binding affinity.
• Ligand & Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Potential monomer or additive for creating specialty polymers with tailored surface properties and chemical resistance.
• Academic & Contract Research: Employed in university and CRO laboratories for methodological studies and the exploration of new chemical spaces in medicinal and synthetic chemistry.

Basic Information

Product Name	Pyrrolidine, 1-Acetyl-2-(2,2,2-Trifluoro-1-Hydroxyethylidene)-, (E)- (9Ci)
CAS No.	148183-87-3
Molecular Formula	C8H10F3NO2
Molecular Weight	209.17 g/mol
Synonyms	1-Acetyl-2-[(E)-(2,2,2-trifluoro-1-hydroxyethylidene)]pyrrolidine; (E)-1-Acetyl-2-(2,2,2-trifluoro-1-hydroxyethylidene)pyrrolidine; 2-(2,2,2-Trifluoro-1-hydroxyethylidene)-1-acetylpyrrolidine; 1-Acetyl-2-(trifluoro-1-hydroxyethylidene)pyrrolidine; 148183-87-3; Pyrrolidine, 1-acetyl-2-[(E)-(2,2,2-trifluoro-1-hydroxyethylidene)]-; (E)-1-Acetyl-2-(2,2,2-trifluoro-1-hydroxyethylidene)pyrrolidine
EINECS	Contact for details

Quality Control

Every batch of Pyrrolidine, 1-Acetyl-2-(2,2,2-Trifluoro-1-Hydroxyethylidene)-, (E)- (9Ci) is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure identity, purity, and consistency for your critical research and development projects. Certificates of Analysis (COA) detailing specifications such as assay (HPLC), chiral purity, and impurity profiles are available for every shipment. Our quality commitment supports compliance with cGMP and ISO standards for advanced chemical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. For long-term storage, it is recommended to keep the material at 2-8°C under an inert atmosphere to maintain stability. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee (E-isomer)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.