Description

Human IL-13 is a critical cytokine protein that plays a central role in regulating immune responses, particularly those associated with type 2 inflammation and allergic diseases. Its precise biological activity makes it an invaluable reagent for life science research and therapeutic development. This high-purity protein is essential for researchers and developers in the pharmaceutical, biotechnology, and diagnostic sectors focusing on immunology, asthma, atopic dermatitis, and novel biologic therapies.

Application

• Biomedical Research: Used as a key reagent in cell-based assays to study Th2 immune responses, allergic inflammation pathways, and cytokine signaling networks.
• Drug Discovery & Development: Serves as a target protein for screening and characterizing potential therapeutic antibodies, inhibitors, or modulators aimed at treating IL-13-mediated diseases.
• Diagnostic Kit Development: Employed as a reference standard or coating antigen in the development and calibration of immunoassays (e.g., ELISA) to detect IL-13 levels in biological samples.
• Cell Culture & Differentiation: Utilized to polarize naive T cells towards a Th2 phenotype or to stimulate specific cell types (e.g., B cells, monocytes) in vitro to model disease states.
• Protein Interaction Studies: Acts as a ligand in surface plasmon resonance (SPR), isothermal titration calorimetry (ITC), or other biophysical techniques to study receptor binding kinetics (e.g., with IL-13Rα1/IL-4Rα).
• Quality Control & Standardization: Functions as a critical quality attribute standard in the manufacturing and lot-release testing of IL-13-targeting biologics.

Basic Information

Product Name	Human IL-13
CAS No.	148157-34-0
Molecular Formula	C600H950N170O190S10 (Approx.)
Molecular Weight	~13 kDa (Glycosylated form)
Synonyms	Interleukin-13; IL-13; ALRH; BHR1; IL13; MGC116786; MGC116788; P600; NC30; Cytokine P600
EINECS	Contact for details

Quality Control

Our Human IL-13 is produced under stringent conditions to ensure the highest levels of purity and biological activity, suitable for sensitive research and development applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, endotoxin levels, sterility, and functional activity data. We adhere to rigorous quality management principles to guarantee batch-to-batch consistency and reliability for our global B2B clients.

Storage

Preserve in a tightly closed container, protected from light. For long-term storage, it is recommended to keep the lyophilized protein at -20°C or below. Reconstituted aliquots should be stored at -70°C to -80°C and avoid repeated freeze-thaw cycles. Due to its hygroscopic (moisture-sensitive) nature, the lyophilized powder should be equilibrated to room temperature in a desiccator before opening to prevent moisture absorption.

Specification

Item	Specification
Appearance	White or off-white lyophilized powder
Purity (SDS-PAGE)	≥ 95%
Purity (HPLC)	≥ 98.0%
Endotoxin Level	< 1.0 EU/μg
Biological Activity	Determined by cell proliferation/ inhibition assay
Sterility	Sterile filtered (0.2 μm)
Reconstitution	Consult COA for specific buffer and concentration

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.