Description

4-(Difluoromethoxy)Benzamide is a high-purity organic compound featuring a benzamide core substituted with a difluoromethoxy group, a structural motif of significant interest in advanced chemical synthesis. This compound serves as a versatile and critical pharmaceutical intermediate and agrochemical building block, enabling the development of novel active ingredients with enhanced properties. It is primarily utilized by R&D and production teams in the pharmaceutical, agrochemical, and specialty chemical industries seeking to incorporate fluorine chemistry for improved metabolic stability and bioactivity.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in drug discovery programs targeting central nervous system (CNS) disorders, inflammation, and metabolic diseases.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the difluoromethoxy group can enhance lipophilicity and biological activity.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands in organometallic chemistry and catalysis.
• Material Science Research: Investigated as a monomer or additive for developing novel polymers with specific thermal or chemical resistance properties.
• Organic Synthesis Reference Standard: Employed as a pure standard in analytical laboratories for method development and quality control.
• Fluorine Chemistry Studies: A valuable compound for academic and industrial research into the effects of fluorine substitution on molecular reactivity and physical properties.

Basic Information

Product Name	4-(Difluoromethoxy)Benzamide
CAS No.	147992-28-7
Molecular Formula	C8H7F2NO2
Molecular Weight	187.14 g/mol
Synonyms	p-(Difluoromethoxy)benzamide; 4-(Difluoromethoxy)benzoic acid amide; Benzamide, 4-(difluoromethoxy)-; Difluoromethoxybenzamide; NSC 405124; AI3-63200; LS-192260; Amide of 4-(difluoromethoxy)benzoic acid
EINECS	Contact for details

Quality Control

Our 4-(Difluoromethoxy)Benzamide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via IR and NMR spectroscopy, to ensure it meets exacting research and production-grade specifications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive). Keep the container tightly sealed in a dry environment to prevent absorption of moisture, which may affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (HPLC, Area %)	≥ 99.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.