Description

Insulinoma-Associated Intronless Protein 1 CAS NO 147955-03-1 is a high-purity biochemical reagent, a synthetic peptide or protein fragment derived from the IA-1 gene, which is a key transcription factor involved in neuroendocrine differentiation. This compound is essential for advanced life science research, particularly in studies of pancreatic β-cell development, insulinoma biology, and neuroendocrine tumor mechanisms. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and diagnostic developers focusing on diabetes, oncology, and developmental biology.

Application

• Biomedical Research: Used as a critical antigen or standard in studies of neuroendocrine differentiation, pancreatic islet cell development, and the molecular pathways of insulinoma.
• Antibody Production & Validation: Serves as an immunogen for generating polyclonal or monoclonal antibodies specific to the Insulinoma-Associated 1 (IA-1/INSM1) protein.
• Diagnostic Assay Development: Employed as a reference standard or calibrator in the development of immunoassays (ELISA, Western Blot) for detecting IA-1 expression in tissue or serum samples.
• Cancer Research: A vital tool for investigating the role of the IA-1 transcription factor in neuroendocrine tumors, including small cell lung carcinoma and medullary thyroid carcinoma.
• Cell Signaling Studies: Facilitates research into the regulatory networks controlling hormone production and secretion in endocrine cells.
• Drug Discovery Screening: Used in target validation and high-throughput screening assays to identify potential therapeutics that modulate IA-1 activity.

Basic Information

Product Name	Insulinoma-Associated Intronless Protein 1
CAS No.	147955-03-1
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	IA-1; INSM1; Insulinoma-associated protein 1; Zinc finger protein IA-1; Insulinoma-associated intronless protein; hINSA1; INSM1 transcription factor; IA1; ZNFIA1
EINECS	Contact for details

Quality Control

Our Insulinoma-Associated Intronless Protein 1 is manufactured under stringent conditions to ensure batch-to-batch consistency and high biological activity. Each lot undergoes rigorous analytical testing, including HPLC for purity and mass spectrometry for identity confirmation. We provide comprehensive Certificates of Analysis (COA) detailing purity, endotoxin levels, and biological activity data to support your critical research and development applications.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This material is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a dry environment before opening to minimize moisture uptake. Aliquot into single-use vials to avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (Mass Spec)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0%
Endotoxin Level (LAL)	< 1.0 EU/µg
Biological Activity	Assessed by functional assay

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.