Description

Rad14 Protein CAS NO 147953-53-5 is a highly purified, recombinant protein essential for DNA damage recognition and nucleotide excision repair (NER) pathways. This protein is critical for researchers and developers focused on understanding and targeting cellular repair mechanisms, genomic stability, and associated disease states. It serves as a vital reagent for the biotechnology, pharmaceutical, and life sciences industries, enabling advanced studies in cancer research, genetic toxicology, and the development of novel therapeutic agents.

Application

• Biochemical Research: Used as a key enzyme in in vitro studies of nucleotide excision repair (NER) mechanisms and DNA damage response.
• Drug Discovery & Screening: Acts as a target protein in high-throughput assays to identify potential inhibitors or modulators of DNA repair for oncology therapeutics.
• Diagnostic Development: Employed in the development of diagnostic kits and assays to detect DNA repair deficiencies or specific protein interactions.
• Academic Research: Essential for university and institutional labs studying genomics, molecular biology, and the molecular basis of diseases like xeroderma pigmentosum.
• Enzyme Characterization: Utilized for kinetic studies, binding affinity measurements, and functional analysis of protein-DNA interactions.
• Reagent Production: Serves as a critical component in the formulation of specialized research-grade reagent kits for molecular biology applications.

Basic Information

Product Name	Rad14 Protein
CAS No.	147953-53-5
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	RAD14 Protein; DNA Repair Protein RAD14; XP-A Protein; Xeroderma Pigmentosum group A-complementing Protein; RAD14 Homolog (S. cerevisiae); hRAD14; ERCC4; Recombinant Human Rad14 Protein
EINECS	Contact for details

Quality Control

Our Rad14 Protein is produced under stringent quality management systems to ensure batch-to-batch consistency and high biological activity. Each lot undergoes comprehensive analytical testing, including purity assessment by SDS-PAGE and HPLC, functional activity assays, and endotoxin level verification. Certificates of Analysis (COA) detailing all specifications are provided to guarantee the product meets the rigorous standards required for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below in a non-frost-free freezer. Avoid repeated freeze-thaw cycles. Aliquot as recommended upon receipt to maintain optimal activity.

Specification

Item	Specification
Appearance	Clear, colorless solution
Purity (SDS-PAGE)	≥ 90%
Protein Concentration	≥ 0.5 mg/mL
Activity (Functional Assay)	Contact for details
Buffer Composition	20 mM Tris-HCl, 200 mM NaCl, 1 mM DTT, 10% Glycerol, pH 8.0
Endotoxin Level	< 1.0 EU/μg
Identification (Mass Spec)	Conforms

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.