Description

Boc-L-4,4'-Biphenylalanine CAS NO 147923-08-8 is a protected, non-natural amino acid derivative featuring a rigid biphenyl side chain. This compound is a critical building block in the synthesis of complex peptides and peptidomimetics, offering enhanced structural diversity and stability. It is primarily utilized by researchers and manufacturers in the pharmaceutical and biotechnology sectors for drug discovery, particularly in developing novel therapeutics targeting protein-protein interactions.

Application

• Pharmaceutical Research & Development: A key intermediate in the solid-phase and solution-phase synthesis of bioactive peptides and constrained peptide analogs.
• Peptidomimetic Design: Used to incorporate a rigid, hydrophobic biphenyl moiety into peptide backbones to improve metabolic stability, bioavailability, and binding affinity.
• Chemical Biology Probes: Employed in the creation of labeled or tagged peptides for studying enzyme mechanisms, receptor-ligand interactions, and cellular pathways.
• Material Science: Serves as a monomer or precursor for synthesizing specialized polymers and advanced materials with unique optical or structural properties.
• Academic & Institutional Research: Utilized in university and laboratory settings for fundamental studies in organic chemistry and medicinal chemistry.

Basic Information

Product Name	Boc-L-4,4'-Biphenylalanine
CAS No.	147923-08-8
Molecular Formula	C₂₀H₂₃NO₄
Molecular Weight	341.41 g/mol
Synonyms	(2S)-2-[(tert-Butoxycarbonyl)amino]-3-[1,1'-biphenyl]-4-ylpropanoic acid; Boc-4-Biphenylalanine-OH; Boc-L-Biphenyl(4,4')-Ala-OH; N-α-Boc-4,4'-biphenyl-L-alanine; tert-Butyloxycarbonyl-4,4'-biphenyl-L-alanine; BOC-Bip(4,4')-Ala-OH; N-(tert-Butoxycarbonyl)-4,4'-biphenyl-L-alanine
EINECS	Contact for details

Quality Control

Our Boc-L-4,4'-Biphenylalanine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral integrity, to ensure it meets the high standards required for research and pharmaceutical applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.