Description

(+)-n-Desmethyl Tramadol CAS NO 147762-57-0 is a high-purity pharmaceutical intermediate and active metabolite of the analgesic Tramadol. This compound is critical for research and development in neuropharmacology and for the synthesis of novel analgesic agents. It is primarily utilized by pharmaceutical R&D laboratories, analytical reference standard providers, and manufacturers of active pharmaceutical ingredients (APIs) for quality control and metabolic studies.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for the quantitative and qualitative analysis of Tramadol and its metabolites in biological matrices and finished drug products.
• Metabolite Research: Essential for in vitro and in vivo studies investigating the pharmacokinetics, pharmacodynamics, and metabolic pathways of Tramadol.
• Analytical Method Development: Serves as a key standard for developing and validating HPLC, LC-MS/MS, and GC-MS methods in bioanalytical and quality control laboratories.
• Impurity Profiling: Employed to identify, quantify, and monitor process-related impurities and degradation products in Tramadol API manufacturing.
• Preclinical & Clinical Studies: Used in pharmacological research to study the specific activity and safety profile of the O-desmethyl metabolite, which is a major contributor to Tramadol's analgesic effect.
• Chemical Synthesis: Acts as a sophisticated building block or precursor in the synthesis of novel opioid receptor ligands and related pharmaceutical compounds.

Basic Information

Product Name	(+)-n-Desmethyl Tramadol
CAS No.	147762-57-0
Molecular Formula	C15H23NO2
Molecular Weight	249.35 g/mol
Synonyms	(+)-O-Desmethyltramadol; (1R,2R)-2-[(Dimethylamino)methyl]-1-(3-methoxyphenyl)cyclohexanol; O-DSMT; (+)-O-DSMT; Metabolite M1 of Tramadol; (1R,2R)-Tramadol Metabolite O-Desmethyl; FAN541; UNII-1O4YV6171Z
EINECS	Contact for details

Quality Control

Our (+)-n-Desmethyl Tramadol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the stringent requirements for pharmaceutical research and reference standard applications. A detailed Certificate of Analysis (COA) providing results for identity, purity (HPLC), chiral content, residual solvents, and related substances is supplied with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (1R,2R enantiomer)
Related Substances (HPLC)	Total impurities ≤2.0% Any single unknown impurity ≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.