Description

Npr1 Protein CAS NO 147682-31-3 is a high-purity recombinant protein, specifically the Natriuretic Peptide Receptor 1, which plays a critical role in cardiovascular and renal physiology. This protein is essential for research and development in the life sciences, serving as a key reagent for studying signaling pathways, receptor-ligand interactions, and for use in assay development. It is primarily utilized by biotechnology firms, academic research institutions, and pharmaceutical companies engaged in drug discovery, particularly for cardiovascular and metabolic diseases.

Application

• Biochemical Research: Used as a standard or target protein in studies of natriuretic peptide signaling and cardiovascular biology.
• Drug Discovery & Screening: Serves as a critical component in high-throughput screening (HTS) assays to identify novel therapeutic compounds targeting the NPR1 receptor.
• Diagnostic Development: Employed in the development and calibration of immunoassays and biosensors for detecting natriuretic peptides or related biomarkers.
• Enzyme-Linked Immunosorbent Assay (ELISA): Used as a coating antigen or standard in ELISA kits for quantitative analysis.
• Protein-Protein Interaction Studies: Essential for investigating binding kinetics and affinity with its natural ligands (ANP, BNP).
• Cell-Based Assays: Utilized in functional cellular assays to study receptor activation and downstream signaling events.

Basic Information

Product Name	Npr1 Protein
CAS No.	147682-31-3
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Natriuretic Peptide Receptor 1; Atrial Natriuretic Peptide Receptor A; ANPRA; Guanylate Cyclase A; GC-A; NPR-A; ANPR-A; Atrial Natriuretic Factor Receptor; ANF Receptor; NPR1; GUCY2A
EINECS	Contact for details

Quality Control

Our Npr1 Protein is produced under stringent conditions to ensure high biological activity and batch-to-batch consistency. Each lot undergoes rigorous quality testing, including purity analysis by SDS-PAGE and HPLC, endotoxin level testing, and functional activity verification. A comprehensive Certificate of Analysis (COA) detailing identity, purity, concentration, and biological activity is provided with every shipment to ensure compliance with research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below in a non-frost-free freezer. Avoid repeated freeze-thaw cycles. The product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder or clear solution
Purity (SDS-PAGE)	≥ 90%
Purity (HPLC)	≥ 95%
Endotoxin Level	< 1.0 EU/µg
Biological Activity	Determined by functional assay (e.g., cGMP production)
Identification (Mass Spec)	Conforms
Solubility	Reconstitutes in appropriate buffer
Protein Concentration	As per COA

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.