Description

(S)-9-Hydroxy Risperidone is a key chiral intermediate and the major active metabolite of the antipsychotic drug Risperidone. This compound is of critical importance for pharmaceutical research and development, particularly in the study of drug metabolism, pharmacokinetics, and the synthesis of advanced active pharmaceutical ingredients (APIs). It is primarily required by pharmaceutical manufacturers, contract research organizations (CROs), and academic institutions engaged in neuropharmacology and central nervous system (CNS) drug development.

Application

• Pharmaceutical Intermediate: Critical chiral building block for the synthesis and research of Risperidone and related analogs.
• Metabolite Standard: Used as a certified reference standard in bioanalytical studies for quantifying Risperidone and its metabolites in biological matrices.
• Pharmacology Research: Essential for in vitro and in vivo studies investigating the metabolic pathway, efficacy, and safety profile of Risperidone.
• Impurity Profiling: Serves as a known impurity or degradation product reference standard for quality control in API manufacturing.
• Analytical Method Development: Used to develop and validate HPLC, LC-MS, and other chromatographic methods for pharmaceutical analysis.
• Drug Discovery: A valuable compound for medicinal chemistry programs aimed at developing new dopamine and serotonin receptor antagonists.

Basic Information

Product Name	(S)-9-Hydroxy Risperidone
CAS No.	147663-01-2
Molecular Formula	C23H27FN4O2
Molecular Weight	410.49 g/mol
Synonyms	(S)-9-Hydroxyrisperidone; Paliperidone Impurity F; (3S)-9-Hydroxyrisperidone; 9-Hydroxy Risperidone (S-isomer); Risperidone Metabolite (9-Hydroxy, S-); (S)-9-OH-Risperidone; Paliperidone Related Compound F; 3-[2-[4-(6-Fluoro-1,2-benzisoxazol-3-yl)piperidino]ethyl]-9-hydroxy-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one (S-)
EINECS	Contact for details

Quality Control

Our (S)-9-Hydroxy Risperidone is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical research and reference standard applications. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, confirming identity, purity, and impurity profile.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing under inert atmosphere at -20°C.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single unknown impurity ≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.