Description

Sen1 Protein CAS NO 147651-18-1 is a high-purity, biologically active protein essential for advanced life science research and development. This product is critical for studies involving DNA replication, transcription, and chromatin remodeling, offering researchers a reliable and consistent reagent. It is primarily utilized by biotechnology firms, academic research institutions, and pharmaceutical companies engaged in molecular biology, enzymology, and drug discovery programs.

Application

• Enzymology Studies: Used as a key substrate or enzyme in assays to study helicase activity, DNA unwinding mechanisms, and protein-nucleic acid interactions.
• Chromatin Research: Essential for investigating the role of Sen1 in transcription termination, chromatin structure regulation, and gene expression control.
• Drug Discovery Screening: Employed in high-throughput screening (HTS) platforms to identify and validate novel inhibitors or modulators targeting Sen1-related pathways.
• Biochemical Reagent: Serves as a critical component in buffer systems and reaction mixtures for in vitro transcription and replication experiments.
• Protein-Protein Interaction Studies: Utilized in pull-down assays, co-immunoprecipitation (Co-IP), and surface plasmon resonance (SPR) to map interaction networks.
• Antibody Production & Validation: Acts as a pure antigen for the generation and quality control of specific polyclonal or monoclonal antibodies.

Basic Information

Product Name	Sen1 Protein
CAS No.	147651-18-1
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Sen1 Helicase; Sen1p; Superfamily 1 Helicase Sen1; SEN1 Saccharomyces cerevisiae; Transcription Termination Factor Sen1; EC 3.6.4.12; SEN1 Gene Product; Yeast Sen1 Protein; NAM1
EINECS	Contact for details

Quality Control

Our Sen1 Protein is produced and tested under stringent quality management systems to ensure batch-to-batch consistency and biological activity. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, activity, and absence of contaminants. We adhere to relevant guidelines for research-grade biological products to support the integrity of your scientific work.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below in aliquots to avoid repeated freeze-thaw cycles. The product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use. Handle under appropriate laboratory conditions.

Specification

Item	Specification
Appearance	White or off-white lyophilized powder
Identification (SDS-PAGE)	Single major band at expected molecular weight
Purity (HPLC)	≥ 95%
Protein Content (BCA)	≥ 90%
Biological Activity (Helicase Assay)	Fully active; specific activity provided on COA
Endotoxin Level (LAL)	< 1.0 EU/µg
Solubility	Soluble in appropriate aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.