Description

Cdkn1B CAS NO 147604-94-2 is a high-purity chemical compound, specifically a cyclin-dependent kinase inhibitor, used as a critical reference standard and research reagent. This compound is essential for biochemical and pharmacological research, enabling the study of cell cycle regulation and the development of targeted therapeutic agents. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and biotechnology companies focused on oncology and cell biology.

Application

• Pharmaceutical Research & Development: Serves as a key reference standard in the discovery and validation of novel CDK inhibitors for cancer therapy.
• Biochemical Assay Development: Used as a precise control compound in enzymatic and cellular assays to study CDK activity and inhibition mechanisms.
• Academic Cell Biology Studies: A vital tool for investigating cell cycle progression, proliferation, and apoptosis in various experimental models.
• Preclinical Drug Evaluation: Employed in comparative studies to assess the potency and selectivity of new therapeutic candidates.
• Quality Control in Manufacturing: Acts as a benchmark for the quality assurance of related active pharmaceutical ingredients (APIs) and finished drug products.

Basic Information

Product Name	Cdkn1B
CAS No.	147604-94-2
Molecular Formula	C₁₉H₁₈N₄O₂
Molecular Weight	334.37 g/mol
Synonyms	p27 Kip1; Cyclin-Dependent Kinase Inhibitor 1B; p27; KIP1; CDKN4; p27Kip1; p27(kip1); (2Z)-5-[(5-Chloro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-N-(2-hydroxyethyl)-2,4-dimethyl-1H-pyrrole-3-carboxamide; Roscovitine analog
EINECS	Contact for details

Quality Control

Our Cdkn1B is manufactured under strict quality management systems to ensure batch-to-batch consistency and reliability for research applications. Each lot undergoes comprehensive analytical testing, including identity confirmation by spectroscopic methods and purity determination by HPLC. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all relevant specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry, cool place. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	Off-white to yellow solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.