Description

(R)-2-Hydroxy-3-Methyl-3-Butenenitrile CAS NO 147600-17-7 is a chiral, non-racemic nitrile derivative that serves as a valuable synthetic intermediate in fine chemical synthesis. Its core value lies in its bifunctional structure, featuring both a hydroxyl group and a nitrile moiety, which allows for versatile chemical transformations to produce complex, optically active molecules. This compound is primarily needed by research and development chemists and process engineers in the pharmaceutical and agrochemical industries for the synthesis of active pharmaceutical ingredients (APIs) and advanced crop protection agents.

Application

• Pharmaceutical Intermediate: A key chiral building block for the synthesis of enantiomerically pure drugs, particularly those targeting central nervous system (CNS) disorders and cardiovascular diseases.
• Agrochemical Synthesis: Used in the production of chiral pesticides, herbicides, and fungicides where specific stereochemistry is crucial for biological activity and environmental safety.
• Asymmetric Catalysis Research: Serves as a model substrate or ligand precursor in the development of new asymmetric catalytic reactions and methodologies.
• Flavor and Fragrance Industry: Employed in the synthesis of complex terpenoids and other odorants where stereochemical purity defines the sensory profile.
• Material Science: Potential monomer or cross-linking agent for creating specialized polymers with unique optical or mechanical properties.

Basic Information

Product Name	(R)-2-Hydroxy-3-Methyl-3-Butenenitrile
CAS No.	147600-17-7
Molecular Formula	C5H7NO
Molecular Weight	97.12 g/mol
Synonyms	(R)-3-Methyl-3-buten-2-ol nitrile; (R)-2-Hydroxy-3-methylbut-3-enenitrile; (R)-2-Methyl-1-cyano-2-propen-1-ol; (R)-3-Methylbut-3-ene-2-carbonitrile; (R)-2-Hydroxy-3-methyl-3-butenenitrile; (R)-HMB Nitrile; (R)-2-Hydroxy-3-methylcrotononitrile
EINECS	Contact for details

Quality Control

Our (R)-2-Hydroxy-3-Methyl-3-Butenenitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC to ensure high enantiomeric excess (ee) and purity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing specifications for identity, assay, chiral purity, and impurity profiles. Our quality commitment aligns with cGMP principles for advanced pharmaceutical intermediates, ensuring traceability and consistency for critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which may affect stability and handling properties. Keep away from strong oxidizing agents and bases.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.