Description

(p-Scn-Bn)-NOTA is a bifunctional chelator featuring a p-isothiocyanatobenzyl group, enabling covalent conjugation to biomolecules, and a NOTA macrocycle for stable complexation of trivalent radiometals. This compound is essential for creating targeted radiopharmaceuticals for diagnostic imaging and therapeutic applications. It is primarily utilized by researchers and manufacturers in the fields of nuclear medicine, radiochemistry, and molecular imaging for developing precise theranostic agents.

Application

• Radiopharmaceutical Precursor: Conjugation to antibodies, peptides, or small molecules for the development of targeted PET (Positron Emission Tomography) and SPECT (Single-Photon Emission Computed Tomography) imaging agents.
• Theranostic Agent Development: Creation of molecules for both diagnostic imaging and targeted radionuclide therapy, particularly using isotopes like Gallium-68, Lutetium-177, and Actinium-225.
• Bioconjugation Chemistry: Serves as a key linker-chelator in the synthesis of novel biomolecular conjugates for research into cancer targeting and biodistribution studies.
• Preclinical Research: Used in academic and industrial R&D for evaluating new targeting vectors and optimizing pharmacokinetic properties of radiometal complexes.
• GMP-Grade Manufacturing: High-purity grades are suitable as a starting material in the cGMP production of clinical-stage and commercial radiopharmaceuticals.

Basic Information

Product Name	(p-Scn-Bn)-NOTA
CAS No.	147597-66-8
Molecular Formula	C19H27N5O6S
Molecular Weight	453.51 g/mol
Synonyms	2,2',2''-(1,4,7-Triazacyclononane-1,4,7-triyl)triacetic acid, 1-(4-Isothiocyanatobenzyl) derivative; NOTA-p-SCN-Bn; p-SCN-Bn-NOTA; 1,4,7-Triazacyclononane-1,4,7-triacetic acid, 1-(p-Isothiocyanatobenzyl); SCN-Bn-NOTA; 2-(4-Isothiocyanatobenzyl)-1,4,7-triazacyclononane-1,4,7-triacetic acid; Bz-SCN-NOTA
EINECS	Contact for details

Quality Control

Our (p-Scn-Bn)-NOTA is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for sensitive bioconjugation and radiochemistry applications. Certificates of Analysis (COA) with detailed specifications are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 2.0%
Solubility	Soluble in DMSO, DMF; slightly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.