Description

Graves' Disease Carrier Protein is a highly purified protein derivative used as a critical reagent in immunological research and diagnostic development. This compound is essential for the study and detection of autoantibodies associated with Graves' disease, an autoimmune thyroid disorder. It serves as a vital component for researchers and manufacturers in the fields of clinical diagnostics, immunology, and pharmaceutical development, enabling the creation of accurate and reliable assays.

Application

• Immunoassay Development: Key antigenic component in the formulation of ELISA (Enzyme-Linked Immunosorbent Assay) and other immunoassay kits for the detection of Thyroid-Stimulating Hormone Receptor Antibodies (TRAb).
• Clinical Diagnostics: Used as a calibrator and control material in automated diagnostic systems for thyroid function testing and autoimmune disease profiling.
• Biomedical Research: Serves as a target antigen in studies investigating the pathogenesis, immunology, and therapeutic interventions for Graves' disease and related autoimmune thyroid conditions.
• Antibody Purification: Employed in affinity chromatography columns for the isolation and purification of specific autoantibodies from patient serum samples.
• Quality Control Reagent: Acts as a reference standard in the quality control and validation processes of diagnostic test kits to ensure batch-to-batch consistency and accuracy.
• Pharmaceutical Screening: Utilized in high-throughput screening (HTS) platforms to identify potential therapeutic compounds that modulate the autoimmune response in Graves' disease.

Basic Information

Product Name	Graves' Disease Carrier Protein
CAS No.	147571-37-7
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Graves' Disease Antigen; Thyroid-Stimulating Hormone Receptor Protein Fragment; TSHR Carrier Protein; Autoimmune Thyroid Disease Antigen; TRAb Assay Antigen; Graves' Immunogen; Thyrotropin Receptor Peptide Conjugate
EINECS	Contact for details

Quality Control

Our Graves' Disease Carrier Protein is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including purity assessment by HPLC, identity confirmation, and biological activity verification to ensure it meets the exacting standards required for diagnostic and research applications. A Certificate of Analysis (COA) detailing all test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccation or storage under inert atmosphere. Keep container tightly sealed when not in use to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 95.0%
Protein Content (Biuret)	≥ 90.0%
Moisture Content (KF)	≤ 5.0%
Biological Activity (ELISA)	Positive binding to reference TRAb serum
Endotoxin Level (LAL)	< 1.0 EU/mg

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.