Description

Tramadol n-Oxide (Mixture Of Diastereomers) is a key pharmaceutical intermediate and metabolite of the centrally acting analgesic tramadol. This compound is of significant interest for research and development in pharmacology and medicinal chemistry, particularly in studies related to drug metabolism, pharmacokinetics, and the synthesis of novel active pharmaceutical ingredients (APIs). It serves as a critical building block for pharmaceutical manufacturers, analytical laboratories, and academic research institutions focused on pain management therapeutics and metabolic pathway analysis.

Application

• Pharmaceutical Intermediate: Serves as a crucial precursor in the synthesis and development of novel analgesic compounds and related pharmaceutical actives.
• Metabolite Reference Standard: Used as a certified reference material (CRM) in analytical laboratories for the identification and quantification of tramadol metabolites in biological samples during pharmacokinetic and toxicology studies.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies to understand the metabolic pathways and optimize the therapeutic profile of opioid analgesics.
• Impurity Standard: Acts as a known impurity standard in the quality control (QC) and stability testing of tramadol hydrochloride API and finished dosage forms to ensure product safety and compliance with ICH guidelines.
• Biochemical Tool: Utilized in in-vitro and in-vivo research to investigate the pharmacological activity and metabolic fate of tramadol and its derivatives.

Basic Information

Product Name	Tramadol n-Oxide (Mixture Of Diastereomers)
CAS No.	147441-56-3
Molecular Formula	C16H25NO3
Molecular Weight	279.38 g/mol
Synonyms	(1R*,2R*)-2-[(Dimethylamino)methyl]-1-(3-methoxyphenyl)cyclohexanol N-Oxide; (1RS,2RS)-2-[(Dimethylamino)methyl]-1-(3-methoxyphenyl)cyclohexanol N-Oxide; Tramadol Metabolite M1 N-Oxide; Tramadol N-Oxide Diastereomeric Mixture; (±)-trans-Tramadol N-Oxide; Tramadol Impurity G (N-Oxide); UNII-9C3B3S6A1T
EINECS	Contact for details

Quality Control

Our Tramadol n-Oxide is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets high-purity standards suitable for research and development. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting batch-specific results for critical parameters such as assay, diastereomeric ratio, and related substances.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (typically 15-25°C). Keep the container tightly sealed in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Diastereomeric Ratio	Specified on COA
Related Substances (HPLC)	Individual impurity ≤ 0.5% Total impurities ≤ 1.5%
Residual Solvents (GC)	Complies with ICH Q3C
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.