Description

Invariant Surface Glycoprotein 65 CAS NO 147338-68-9 is a specialized biochemical reagent of significant interest in parasitology and immunology research. This compound is a key antigenic component, primarily used in the study and diagnosis of African trypanosomiasis (sleeping sickness). It is essential for researchers and diagnostic manufacturers focused on developing sensitive assays and vaccines for protozoan diseases, offering a critical tool for advancing tropical disease research and public health initiatives.

Application

• Diagnostic Assay Development: A critical antigen for the development of ELISA, lateral flow, and other immunoassays for the detection of Trypanosoma brucei infections.
• Vaccine Research: Serves as a target antigen in immunological studies aimed at developing vaccines against African trypanosomiasis.
• Parasitology Studies: Used in fundamental research to understand the surface protein expression, antigenic variation, and host-parasite interactions of trypanosomes.
• Antibody Production & Purification: Employed as an immunogen for generating specific polyclonal or monoclonal antibodies for research and diagnostic use.
• Serological Survey Tools: Incorporated into tools for epidemiological studies to monitor disease prevalence in endemic regions.
• Biomarker Investigation: Studied as a potential biomarker for disease staging and treatment efficacy monitoring.

Basic Information

Product Name	Invariant Surface Glycoprotein 65
CAS No.	147338-68-9
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	ISG 65; Invariant Surface Glycoprotein 65; Trypanosoma brucei ISG65; VSG-related invariant surface glycoprotein; Glycoprotein, invariant surface, 65; TbISG65
EINECS	Contact for details

Quality Control

Our Invariant Surface Glycoprotein 65 is produced and tested to meet the stringent requirements of research and diagnostic applications. Each batch undergoes rigorous analytical characterization to ensure identity, purity, and biological activity. A comprehensive Certificate of Analysis (COA) detailing purity (by HPLC), identity confirmation, and other relevant parameters is provided with every shipment to guarantee traceability and consistency for your critical work.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Protein Content (BCA)	≥ 90%
Biological Activity (ELISA)	Reactive with specific antisera
Endotoxin (LAL)	< 1.0 EU/μg
Solubility	Soluble in aqueous buffers or DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.