Description

(S,S)-I-Pr-Duphos CAS NO 147253-69-8 is a high-purity, chiral bisphosphine ligand widely recognized for its exceptional performance in asymmetric hydrogenation and other transition metal-catalyzed reactions. Its value lies in enabling the production of enantiomerically pure intermediates and active pharmaceutical ingredients (APIs) with high selectivity and yield. This product is essential for R&D chemists and process engineers in the pharmaceutical, agrochemical, and fine chemical industries who require reliable, high-performance catalysts for chiral synthesis.

Application

• Asymmetric hydrogenation of prochiral olefins, ketones, and imines for pharmaceutical intermediate synthesis.
• Key ligand in the preparation of chiral catalysts for the production of enantiomerically pure Active Pharmaceutical Ingredients (APIs).
• Catalytic asymmetric C-C and C-X bond-forming reactions in advanced fine chemical manufacturing.
• Research and development of novel catalytic processes in academic and industrial laboratories.
• Process development and scale-up for the synthesis of chiral agrochemicals and flavors/fragrances.
• Used in conjunction with rhodium, iridium, and ruthenium metal precursors to form highly active catalytic complexes.

Basic Information

Product Name	(S,S)-I-Pr-Duphos
CAS No.	147253-69-8
Molecular Formula	C26H32P2
Molecular Weight	406.48 g/mol
Synonyms	(1S,1'S)-1,1'-Bis(diisopropylphosphino)ferrocene; (S,S)-1,1'-Bis(diisopropylphosphino)ferrocene; (S,S)-1,1'-Bis(di-iso-propylphosphino)ferrocene; (S,S)-Bis(diisopropylphosphino)ferrocene; (S,S)-iPr-DuPhos; (S,S)-DuPhos-iPr; (S,S)-DiPFc; DuPhos ligand; JosiPhos-type ligand
EINECS	Contact for details

Quality Control

Our (S,S)-I-Pr-Duphos is manufactured under strict quality management systems to ensure batch-to-batch consistency and high chemical purity. Each lot undergoes comprehensive analytical testing, including chiral purity verification by HPLC and 31P NMR spectroscopy. Certificates of Analysis (COA) detailing identity, assay, and impurity profiles are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry place at 2-8°C for long-term stability. This material is easily oxidized and moisture-sensitive; ensure containers are sealed immediately after use to prevent degradation.

Specification

Item	Specification
Appearance	Orange to red-brown crystalline solid or powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
31P NMR	Conforms
Solubility	Soluble in common organic solvents (THF, toluene, DCM)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.