Description

(-)-1,2-Bis[(2R,5R)-2,5-Dimethylphospholano]Benzene is a high-value, chiral bisphosphine ligand, a critical component in asymmetric catalysis. Its primary value lies in enabling highly enantioselective transformations, particularly in hydrogenation reactions, which are essential for producing single-enantiomer pharmaceutical intermediates and fine chemicals. This ligand is indispensable for R&D and production chemists in the pharmaceutical, agrochemical, and advanced materials sectors who require precise stereochemical control.

Application

• Asymmetric Hydrogenation Catalysis: A premier ligand for the enantioselective hydrogenation of dehydroamino acids, enamides, ketones, and other prochiral substrates.
• Pharmaceutical Intermediate Synthesis: Critical for the production of chiral active pharmaceutical ingredients (APIs), including amino acid derivatives and other complex molecules.
• Agrochemical Manufacturing: Used in the synthesis of enantiomerically pure herbicides, fungicides, and plant growth regulators.
• Academic & Industrial R&D: A key tool for developing new catalytic methodologies and exploring novel synthetic routes in process chemistry.
• Fine Chemical Production: Enables the commercial-scale manufacture of specialty chemicals with high optical purity for flavors, fragrances, and electronic materials.
• Catalyst Screening Libraries: Serves as a benchmark or component in high-throughput screening for new asymmetric reactions.

Basic Information

Product Name	(-)-1,2-Bis[(2R,5R)-2,5-Dimethylphospholano]Benzene
CAS No.	147253-67-6
Molecular Formula	C18H28P2
Molecular Weight	306.36 g/mol
Synonyms	(-)-1,2-Bis[(2R,5R)-2,5-dimethylphospholano]benzene; (R,R)-Me-DuPhos; (2R,2'R,5R,5'R)-1,1'-(1,2-Phenylene)bis(2,5-dimethylphospholane); DuPhos ligand (Me-substituted); (R,R)-1,2-Bis(2,5-dimethylphospholano)benzene; (R,R)-Me-BPE; (2R,5R)-2,5-Dimethylphospholane benzene derivative
EINECS	Contact for details

Quality Control

Our production of (-)-1,2-Bis[(2R,5R)-2,5-Dimethylphospholano]Benzene adheres to stringent quality protocols to ensure batch-to-batch consistency and high chiral purity, which is critical for catalytic performance. All materials are characterized by advanced analytical techniques including NMR, HPLC, and chiral analysis. Certificates of Analysis (COA) detailing identity, purity, and enantiomeric excess are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) at 2-8°C to prevent oxidation and degradation. Keep the container in a cool, dry, well-ventilated place separate from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline solid or powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Solubility Test	Soluble in common organic solvents (e.g., Toluene, THF, DCM)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.