Description

2-(n-Fmoc-4-Aminobutyl)-1,3-Propanediol is a specialized bifunctional building block designed for solid-phase peptide synthesis (SPPS) and other advanced organic synthesis applications. This compound is critical for researchers and manufacturers requiring precise control over molecular architecture, particularly in the development of peptide-based therapeutics and complex biomolecules. Its primary value lies in providing a protected amine group (Fmoc) and two hydroxyl groups, enabling selective and sequential chemical modifications on a stable scaffold. Key industries that utilize this intermediate include pharmaceutical R&D, biotechnology, and fine chemical production for creating novel drug candidates and diagnostic agents.

Application

• Solid-Phase Peptide Synthesis (SPPS): Serves as a versatile linker or spacer molecule for attaching peptides to resin supports, facilitating the synthesis of complex or modified peptides.
• Dendrimer and Polymer Synthesis: Acts as a core branching unit or monomer for constructing dendrimers, star polymers, and other highly branched macromolecular structures.
• Bioconjugation: Used to create functionalized platforms for linking peptides, proteins, or other biomolecules to surfaces, nanoparticles, or fluorescent dyes.
• Prodrug Development: Employed in the design of prodrugs where the diol and protected amine functionalities allow for controlled drug release mechanisms.
• Combinatorial Chemistry: A valuable scaffold in generating diverse chemical libraries for high-throughput screening in drug discovery programs.
• Material Science: Incorporated into specialty coatings or hydrogels where its functional groups contribute to cross-linking and material properties.

Basic Information

Product Name	2-(n-Fmoc-4-Aminobutyl)-1,3-Propanediol
CAS No.	147190-31-6
Molecular Formula	C22H27NO5
Molecular Weight	385.46 g/mol
Synonyms	1,3-Propanediol, 2-[4-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]butyl]-; Fmoc-4-Amino-1,3-butanediol; 2-(4-(Fmoc-amino)butyl)-1,3-propanediol; N-Fmoc-4-amino-1,3-butanediol; Fmoc-Ado-OH; Fmoc-4-Aminobutyl-1,3-propanediol; 4-(Fmoc-amino)butane-1,3-diol; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-4-amino-1,3-butanediol
EINECS	Contact for details

Quality Control

Every batch of 2-(n-Fmoc-4-Aminobutyl)-1,3-Propanediol is produced and tested under strict quality management systems to ensure the highest standards of purity and consistency required for sensitive synthetic applications. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request, detailing key parameters such as purity, identity, and impurity profiles. We adhere to cGMP guidelines where applicable to support our clients in pharmaceutical and biotech development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.