Description

Heat-Shock Protein 82 (HSP82) is a highly conserved molecular chaperone belonging to the Hsp90 family, crucial for cellular homeostasis under stress conditions. This protein plays a vital role in the correct folding, stabilization, and activation of a diverse array of client proteins, many of which are involved in signal transduction and cell cycle regulation. It is an essential research reagent for scientists in biochemistry, molecular biology, and pharmaceutical development, particularly in studies focused on cancer, neurodegenerative diseases, and stress response pathways. The product is supplied with the CAS Registry Number 147096-66-0.

Application

• Biochemical Research: Used as a key reagent in studies of protein folding, chaperone mechanisms, and cellular stress responses.
• Drug Discovery & Target Validation: Serves as a critical target for the development of Hsp90 inhibitors in oncology and other therapeutic areas.
• In Vitro Assay Development: Employed in high-throughput screening (HTS) assays to identify novel modulators of Hsp90 activity.
• Structural Biology: Utilized in X-ray crystallography, NMR, and cryo-EM studies to understand the structure-function relationship of the Hsp90 chaperone cycle.
• Antibody & Diagnostic Production: Acts as an antigen for the generation of specific antibodies used in research and diagnostic kits.
• Cell Signaling Studies: Investigated for its role in stabilizing kinases, transcription factors, and steroid hormone receptors.

Basic Information

Product Name	Heat-Shock Protein 82
CAS No.	147096-66-0
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	HSP82; Hsp90; Heat Shock Protein 90; EC 3.6.4.10; Molecular Chaperone Hsp90; 86 kDa Heat-Shock Protein; Hsp86; Hsp90AA1; HSPC1; HSPCA; Lipopolysaccharide-associated protein 2; LAP-2
EINECS	Contact for details

Quality Control

Our Heat-Shock Protein 82 is produced and handled under stringent quality systems. Each batch undergoes rigorous analytical testing, including purity assessment by SDS-PAGE and HPLC, to ensure consistency and biological activity. A comprehensive Certificate of Analysis (COA), detailing purity, concentration, buffer composition, and functional activity data, is provided with every shipment to support your research and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C to -80°C. Avoid repeated freeze-thaw cycles. This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use. Handle using standard laboratory precautions for biological materials.

Specification

Item	Specification
Appearance	Clear to slightly opalescent solution
Purity (SDS-PAGE)	≥ 90%
Protein Concentration	≥ 1 mg/mL
Buffer Composition	Specified on COA
Biological Activity	ATPase activity confirmed
Endotoxin Level	< 1.0 EU/μg

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.