Description

Proto-Oncogene Protein Int-3 CAS NO 146991-60-8 is a high-purity biochemical reagent of significant interest in advanced life science research. This compound is crucial for studying intracellular signaling pathways and the molecular mechanisms underlying cellular development and oncogenesis. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and biotechnology companies engaged in cancer biology, developmental biology, and targeted therapeutic discovery.

Application

• Biochemical Research: Used as a key reagent in fundamental studies of Notch signaling pathways and their role in cell fate determination.
• Oncology Research: Essential for investigating the molecular basis of oncogenesis, particularly in studies related to the Int-3/Notch4 gene and its protein product.
• Drug Discovery & Development: Serves as a critical reference standard and target protein in high-throughput screening assays for novel cancer therapeutics.
• Academic & Institutional Research: Employed in university and government laboratory settings for proteomics, signal transduction, and gene expression studies.
• Diagnostic Development: Potential use as an antigen or calibrator in the development of immunoassays and diagnostic kits for research purposes.
• Cell Biology Studies: Applied in experiments analyzing protein-protein interactions, intracellular localization, and post-translational modifications.

Basic Information

Product Name	Proto-Oncogene Protein Int-3
CAS No.	146991-60-8
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Int-3 Protein; Notch4 Protein; Notch 4; hNotch4; Proto-Oncogene Int-3; INT3 Oncogene Protein; Notch4 Intracellular Domain; Notch4 ICD; Translocation-Associated Notch Protein TAN-1
EINECS	Contact for details

Quality Control

Our Proto-Oncogene Protein Int-3 is produced and handled under stringent quality management protocols to ensure batch-to-batch consistency and reliability for sensitive research applications. Each lot is accompanied by comprehensive analytical documentation. Certificates of Analysis (COA) detailing purity, identity, and biological activity are available upon request, supporting compliance with rigorous research and development standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and prevent degradation. Allow the vial to equilibrate to room temperature in a desiccator before opening.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 95%
Protein Content (BCA)	≥ 90%
Biological Activity	Assay-dependent; Contact for details
Endotoxin Level (LAL)	< 1.0 EU/µg
Solubility	Soluble in appropriate aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.