Description

Fmoc-Lys(Aloc)-Oh CAS NO 146982-27-6 is a protected amino acid derivative, specifically an Fmoc- and Aloc-protected lysine building block, essential for solid-phase peptide synthesis (SPPS). This compound is critical for researchers and manufacturers requiring precise, orthogonal deprotection strategies to construct complex peptides and bioconjugates. It is primarily used by pharmaceutical R&D teams, biotechnology companies, and CROs/CDMOs engaged in the development of therapeutic peptides, peptide-based drugs, and advanced biomaterials.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key building block for the controlled, sequential assembly of peptide chains on resin.
• Orthogonal Protection Strategy: Enables selective deprotection of the Aloc group in the presence of the Fmoc group, allowing for the synthesis of branched or side-chain modified peptides.
• Therapeutic Peptide Development: Used in the research and production of peptide-based pharmaceuticals, including hormones, antimicrobial peptides, and targeted therapeutics.
• Bioconjugation and Labeling: Serves as a precursor for introducing functional handles (via the deprotected lysine side chain) for attaching dyes, tags, or drug payloads.
• Combinatorial Chemistry: A valuable reagent in libraries for drug discovery and structure-activity relationship (SAR) studies.
• Material Science: Employed in the creation of peptide-functionalized surfaces, hydrogels, and other biomimetic materials.

Basic Information

Item	Detail
Product Name	Fmoc-Lys(Aloc)-Oh
CAS No.	146982-27-6
Molecular Formula	C25H28N2O6
Molecular Weight	452.50 g/mol
Synonyms	Fmoc-Lys(Alloc)-OH; Nα-Fmoc-Nε-Aloc-L-lysine; Fmoc-L-lysine(Aloc)-OH; Fmoc-Lys(Allyloxycarbonyl)-OH; (2S)-6-[(Prop-2-en-1-yloxy)carbonylamino]-2-(9H-fluoren-9-ylmethoxycarbonylamino)hexanoic acid; Nα-(9-Fluorenylmethoxycarbonyl)-Nε-(allyloxycarbonyl)-L-lysine; Fmoc-Lys(Alloc)-OH; Fmoc-Lys(Aloc)
EINECS	Contact for details

Quality Control

Our Fmoc-Lys(Aloc)-Oh is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and chiral analysis to ensure enantiomeric purity. Certificates of Analysis (COA) with detailed chromatograms and spectral data are provided to guarantee compliance with your research and cGMP-grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere for long-term stability. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed container to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.5%
Specific Rotation	Contact for details
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.