Description

Z-Hyp(Tbu)-Ome is a protected amino acid derivative, specifically the tert-butyloxycarbonyl (Boc) and methyl ester-protected form of trans-4-hydroxy-L-proline. This compound is a critical building block in the synthesis of complex peptides and peptidomimetics, offering orthogonal protection strategies for the hydroxyproline side chain. It is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors who require high-purity intermediates for solid-phase peptide synthesis (SPPS) and the development of novel therapeutic agents.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key intermediate for the controlled incorporation of 4-hydroxyproline into peptide chains.
• Pharmaceutical Research: Used in the development of collagenase inhibitors, antiviral drugs, and other bioactive peptides targeting various diseases.
• Bioconjugation: Serves as a precursor for creating peptide-based linkers and probes in bioconjugation chemistry.
• Glycopeptide Synthesis: Facilitates the synthesis of glycopeptides where hydroxyproline acts as a glycosylation site.
• Combinatorial Chemistry: Employed in the generation of diverse peptide libraries for high-throughput screening.
• Process Development: Used in scaling up the production of peptide-based active pharmaceutical ingredients (APIs).

Basic Information

Product Name	Z-Hyp(Tbu)-Ome
CAS No.	146951-99-7
Molecular Formula	C18H25NO6
Molecular Weight	351.40 g/mol
Synonyms	Nα-Z-trans-4-Hydroxy-L-proline tert-butyl ester methyl ester; N-Cbz-trans-4-Hydroxy-L-proline tert-butyl ester methyl ester; (2S,4R)-1-[(Benzyloxy)carbonyl]-4-[(1,1-dimethylethoxy)carbonyloxy]-2-pyrrolidinecarboxylic acid methyl ester; Z-Hyp(OtBu)-OMe; Fmoc-Hyp(OtBu)-OH (related); Boc-Hyp(OtBu)-OH (related); N-Carbobenzoxy-4-hydroxy-L-proline tert-butyl ester methyl ester
EINECS	Contact for details

Quality Control

Our Z-Hyp(Tbu)-Ome is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting the high standards required for pharmaceutical research and development. A comprehensive Certificate of Analysis (COA) detailing purity (typically ≥98% by HPLC), chiral purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.