Description

Ziprasidone is a high-purity pharmaceutical active ingredient, a benzisothiazolyl piperazine derivative, primarily used as an atypical antipsychotic agent. Its primary commercial value lies in its critical role in the formulation of finished dosage forms for the treatment of schizophrenia and acute manic or mixed episodes associated with bipolar disorder. This compound is essential for pharmaceutical manufacturers, research institutions, and contract development and manufacturing organizations (CDMOs) engaged in the production of central nervous system (CNS) therapeutics.

Application

• Pharmaceutical Active Ingredient (API): Primary use in the manufacture of oral capsules and other solid dosage forms.
• Reference Standard: Serves as a certified reference material (CRM) for analytical method development, validation, and quality control testing in laboratories.
• Research & Development: Used in preclinical and clinical studies to investigate pharmacological profiles, metabolism, and new therapeutic applications.
• Generic Drug Manufacturing: A key component for companies producing bioequivalent generic versions of antipsychotic medications.
• Formulation Development: Employed in the development of novel drug delivery systems to enhance stability, bioavailability, or patient compliance.

Basic Information

Item	Detail
Product Name	Ziprasidone
CAS No.	146929-27-7
Molecular Formula	C21H21ClN4OS
Molecular Weight	412.94 g/mol
Synonyms	5-[2-[4-(1,2-Benzisothiazol-3-yl)-1-piperazinyl]ethyl]-6-chloro-1,3-dihydro-2H-indol-2-one; Zeldox; Geodon; CP-88059; 1,2-Benzisothiazol-3-yl 4-(6-chloro-2-oxo-1,3-dihydroindol-5-yl)ethylpiperazine; Ziprasidone Hydrochloride (salt form); Ziprasidone Mesylate (salt form)
EINECS	Contact for details

Quality Control

Our Ziprasidone is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including identification, assay, impurity profiling, and residual solvent analysis, to ensure it meets stringent pharmacopeial standards. A Certificate of Analysis (COA) detailing all test results is provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a low-humidity environment. For long-term storage, consider the use of desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity: ≤ 0.5% Total impurities: ≤ 1.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.