Description

Polyhomeotic Protein CAS NO 146888-72-4 is a high-purity, biologically active protein complex integral to epigenetic regulation and chromatin remodeling processes. This product is essential for researchers and developers requiring a reliable and consistent reagent for advanced molecular biology and genetic studies. It is primarily utilized in academic research, pharmaceutical R&D, and biotechnology applications focused on gene expression, developmental biology, and disease mechanism investigation.

Application

• Epigenetics Research: Used as a key component in studies of Polycomb group (PcG) protein complexes and their role in gene silencing.
• Chromatin Analysis: Employed in assays to investigate chromatin structure, histone modification, and nucleosome positioning.
• Protein-Protein Interaction Studies: Serves as a critical reagent in pull-down assays, co-immunoprecipitation (Co-IP), and mass spectrometry to map interactomes.
• Cell Fate & Developmental Biology: Applied in research on stem cell differentiation, embryonic development, and cellular identity maintenance.
• Drug Discovery Screening: Utilized in target-based screening platforms to identify potential therapeutics that modulate epigenetic pathways.
• Biochemical Assay Development: Acts as a standard or control in developing and validating new enzymatic or binding assays related to chromatin regulators.

Basic Information

Product Name	Polyhomeotic Protein
CAS No.	146888-72-4
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	PH Protein; Polyhomeotic Homolog Protein; PcG Protein; Chromobox Homolog 8 (CBX8) complex protein; Polycomb Group Protein; Posterior Sex Combs Protein; RING Finger Protein 110; RNF110; Chromatin Regulatory Protein
EINECS	Contact for details

Quality Control

Our Polyhomeotic Protein is produced under stringent conditions to ensure batch-to-batch consistency and biological activity. Each lot undergoes rigorous quality testing, including purity analysis by SDS-PAGE and HPLC, functional activity assays, and endotoxin level checks. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and activity is provided with every shipment to support your research and compliance needs.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below in aliquots to avoid repeated freeze-thaw cycles. The product is hygroscopic (moisture-sensitive); ensure the container is sealed under inert atmosphere or desiccant when not in use. Handle under appropriate laboratory conditions.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder or solution
Identification (SDS-PAGE/Western Blot)	Conforms
Purity (SDS-PAGE)	≥ 90%
Purity (HPLC)	≥ 95%
Biological Activity (Functional Assay)	Conforms
Endotoxin Level (LAL Test)	< 1.0 EU/µg
Protein Concentration (UV/BCA)	As per COA
Solubility / Buffer	Specified on COA

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.